Mechanisms of action of fluvoxamine for COVID-19: a historical review

Y Hashimoto, T Suzuki, K Hashimoto - Molecular psychiatry, 2022 - nature.com
… old SSRI fluvoxamine may be new hope for the COVID-19 pandemic [22]. In this article, we
review the mechanisms of action of fluvoxamine and other antidepressants for COVID-19 and …

[HTML][HTML] Fluvoxamine: a review of its mechanism of action and its role in COVID-19

VP Sukhatme, AM Reiersen, SJ Vayttaden… - Frontiers in …, 2021 - frontiersin.org
Fluvoxamine is also an agonist for the sigma-1 receptor, through which it controls …
mechanisms of action of fluvoxamine and other SSRIs that could play a role in COVID-19 treatment. …

Overview of the potential use of fluvoxamine for COVID-19 and long COVID

K Hashimoto - Discover Mental Health, 2023 - Springer
… we cannot conclude the beneficial effects of fluvoxamine for COVID-19. However, several
non-… Considering the role of sigma-1 receptor in mechanisms of action of SARS-CoV-2 [10, 11], …

Old drug fluvoxamine, new hope for COVID-19

Y Hashimoto, T Suzuki, K Hashimoto - European archives of psychiatry …, 2022 - Springer
action of fluvoxamine for COVID-19 are currently unknown. In 1996, we reported that fluvoxamine
… sigma-1 receptor in the mechanisms of its action [5]. Subsequent studies suggest that …

[HTML][HTML] Fluvoxamine for the treatment of COVID-19

C Marzolini, F Marra, A Boyle, S Khoo… - The Lancet Global …, 2022 - thelancet.com
… The authors mentioned that the findings of their study, together with fluvoxamine's safety, …
of COVID-19. We wish to comment further to raise awareness of the fact that fluvoxamine has a …

Lack of Benefit of Fluvoxamine for COVID-19

A Bhimraj, JC Gallagher - JAMA, 2023 - jamanetwork.com
… to demonstrate that fluvoxamine is effective for the treatment of mild to moderate COVID-19. …
from earlier trials on fluvoxamine? A more practical question for frontline clinicians is: Does …

[HTML][HTML] Fluvoxamine for the treatment of COVID-19

MG Dodds, EB Doyle, AM Reiersen, F Brown… - The Lancet Global …, 2022 - thelancet.com
… virus, neither fluvoxamine nor fluoxetine appeared promising … of the potential mechanism
of action assessed in these … generic selective serotonin reuptake inhibitors for COVID-19. …

[HTML][HTML] Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial

EJ Lenze, C Mattar, CF Zorumski, A Stevens… - Jama, 2020 - jamanetwork.com
… The scare of COVID-19 is high and a drug like fluvoxamine is … between COVID-19 and
psychiatric disorders (2). Almost 1 in 5 … Its mechanism of action may include the fact that it can …

Higher-dose fluvoxamine and time to sustained recovery in outpatients with COVID-19: the ACTIV-6 randomized clinical trial

…, E Shenkman, AF Hernandez, S Naggie, A COVID… - JAMA, 2023 - jamanetwork.com
… medications for mild to moderate COVID-19. Between August 25, … fluvoxamine; participants
were 30 years or older with confirmed SARS-CoV-2 infection and at least 2 acute COVID-19

Fluvoxamine for the treatment of COVID19

Cochrane Haematology Group… - Cochrane Database …, 1996 - cochranelibrary.com
fluvoxamine as an early treatment for mild COVID19 in 1649 self‐isolated people at home
(outpatients). All studies compared fluvoxamine to … mechanisms of action of fluvoxamine and …