Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients

B Buijsers, C Yanginlar, ML Maciej-Hulme… - …, 2020 - thelancet.com
… doses of heparin/LMWH in COVID-19 patients. In addition, identification of specific heparin-…
potential for COVID-19 patients, and patients suffering from other inflammatory diseases. …

Heparin as a therapy for COVID-19: current evidence and future possibilities

JA Hippensteel, WB LaRiviere… - … of Physiology-Lung …, 2020 - journals.physiology.org
… Finally, we discuss potential risks associated with the implementation of heparin for the
treatment of SARS-CoV-2, including but not limited to bleeding and immune-mediated …

Potential of heparin and nafamostat combination therapy for COVID19

H Asakura, H Ogawa - Journal of Thrombosis and Haemostasis, 2020 - jthjournal.org
… of COVID-19. Tang et al reported that heparin (particularly low molecular weight heparin) …
In Japan, anticoagulants used for DIC include heparin as well as antithrombin concentrates, …

Comprehensive landscape of heparin therapy for COVID-19

C Shi, W Tingting, JP Li, MA Sullivan, C Wang… - Carbohydrate …, 2021 - Elsevier
… In this review, we comprehensively discussed the potential of heparin therapy for COVID-19.
With multi-functions including its anticoagulant, anti-inflammatory and antiviral activities, …

Should we consider heparin prophylaxis in COVID-19 patients? a systematic review and meta-analysis

M Abdel-Maboud, A Menshawy, A Elgebaly… - Journal of thrombosis …, 2021 - Springer
… These findings come against several preliminary reports suggesting the potential role of
heparin in reducing mortality [5]. Meanwhile, regression models (Fig. 1b) revealed no significant …

The benefits of heparin use in COVID-19: pleiotropic antiviral activity beyond anticoagulant and anti-inflammatory properties

G Lippi, BM Henry, EJ Favaloro - Seminars in Thrombosis and …, 2023 - thieme-connect.com
… for the importance of heparin usage in COVID-19.[27] In fact, the antiviral activity of heparin
may … sprays are undergoing clinical trials to evaluate their potential to mitigate SARS-CoV-2 …

The potential of low molecular weight heparin to mitigate cytokine storm in severe COVID19 patients: a retrospective cohort study

C Shi, C Wang, H Wang, C Yang, F Cai… - Clinical and …, 2020 - Wiley Online Library
… of LMWH as a potential therapeutic drug for the treatment of COVID-19, paving the way …
heparin/LMWH for the treatment of COVID-19, our study signifies an additional activity of heparin

Using heparin molecules to manage COVID‐2019

J Liu, J Li, K Arnold, R Pawlinski… - Research and practice …, 2020 - Wiley Online Library
… One potential advantage of using CS-E 19-mer is that the oligosaccharide does not cross …
and COVID-19 is under way. We believe that the beneficial effects of unfractionated heparin

Heparin for moderately ill patients with Covid-19

M Sholzberg, GH Tang, H Rahhal, M AlHamzah… - medRxiv, 2021 - medrxiv.org
… , in addition to its anticoagulant properties, has anti-inflammatory and potential anti… heparin
compared with usual care using lower doses of heparin in hospitalized patients with Covid-19

Coagulopathy, thromboembolic complications, and the use of heparin in COVID-19 pneumonia

L Costanzo, FP Palumbo, G Ardita, PL Antignani… - Journal of Vascular …, 2020 - Elsevier
… and a potential antiviral effect. We hypothesized that low-molecular-weight heparin may
attenuate cytokine storm in COVID-19 … In this paper, we review potential mechanisms involved in …