Reactive oxygen species induce different cell death mechanisms in cultured neurons

A Valencia, J Morán - Free Radical Biology and Medicine, 2004 - Elsevier
Neuronal apoptotic death involves the participation of reactive oxygen species (ROS), which
… In this study we evaluated the role of different ROS in neuronal death. Superoxide anion …

Reactive oxygen species modulate the differentiation of neurons in clonal cortical cultures

M Tsatmali, EC Walcott, H Makarenkova… - Molecular and Cellular …, 2006 - Elsevier
… We report that rat cortical progenitors in clonal culture produce two types of neurons with
different electrical and biochemical properties. Decreasing ROS in the clonal cultures of …

… reactive oxygen species, release of L-glutamate and activation of caspases are required for oxygen-induced apoptosis of embryonic hippocampal neurons in culture

Y Ishikawa, T Satoh, Y Enokido, C Nishio, T Ikeuchi… - Brain research, 1999 - Elsevier
… is a useful in vitro model of neuronal apoptosis to study the molecular … reactive oxygen
species and glutamate in the high (50%) oxygen-induced death of cultured hippocampal neurons. …

Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture

E Lopez, C Arce, MJ Oset-Gasque, S Canadas… - Free Radical Biology …, 2006 - Elsevier
neurons in culture. This death could be mediated by an apoptotic and a necrotic mechanism.
The apoptotic death may be mediated by oxidative stress with reactive oxygen species (…

Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation

IJ Reynolds, TG Hastings - Journal of Neuroscience, 1995 - Soc Neuroscience
… duction of reactive oxygen species (ROS) in cultured neurons … tirilizad, can partially protect
cultured neurons from NMDA … in the sequence of events surrounding neuronal death. This is a …

Glutathione metabolism in brain: metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species

R Dringen, JM Gutterer… - European journal of …, 2000 - Wiley Online Library
oxygen species is an essential task within the brain. An important component of the cellular
detoxification of reactive oxygen species … brain astrocytes and neurons in culture. These two …

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

J Busciglio, BA Yankner - Nature, 1995 - nature.com
… life":"", consistent with our finding that DS neurons initially survive and differentiate in
culture and then subsequently degenerate. These observations also raise the possibility that a …

Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species

J Tanaka, K Toku, B Zhang, K Ishihara, M Sakanaka… - Glia, 1999 - Wiley Online Library
… Solely cultured neurons, which were transiently exposed to … of DNA fragmentation, whereas
neurons cocultured with either … This medium for neuronal culture was referred to as N-…

Generation of hydrogen peroxide during brief oxygen‐glucose deprivation induces preconditioning neuronal protection in primary cultured neurons

T Furuichi, W Liu, H Shi, M Miyake… - Journal of neuroscience …, 2005 - Wiley Online Library
… specific reactive species? … species provide similar neuronal protection? We measured the
generation of superoxide and hydrogen peroxide levels during IPC in primary cultured neurons

Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity

DG Nicholls, L Johnson‐Cadwell… - Journal of …, 2007 - Wiley Online Library
oxygen species that damage and ultimately killed the neuron. … of in situ mitochondria in
cultured neurons. Applying these … that enhanced reactive oxygen species are a consequence …