… mice, or by backcrossing to well-defined inbred strains in a reasonably short period of time.
However, anatomic and immunologic differences between mice … different CF mouse models …

… Cystic fibrosis in the mouse by targeted insertional mutagenesis. … the exon 10 insertional
cystic fibrosis mutant mouse is a consequence … Porteous, DJ Mouse models for cystic fibrosis. in …

… pathogenesis of the lung disease of cystic fibrosis, as well as … mouse in studying the
pathogenesis of cystic fibrosis has … strain of CFTR-knockout mouse that develops spontaneous …

… modified mice have been studied for more than fifteen years as models of cystic fibrosis (CF).
The … CF mice have also been used to test experimental therapies prior to clinical trials. This …

… mice carrying the most common mutation in cystic fibrosis (CF), AF508, within the cystic fibrosis
(… AF508“ mice die from peritonitis and show deficiencies in cAMP-activated electrogenic …

… Mutations in the gene causing the fatal disease cystic fibrosis (CF) result in abnormal … cloned,
the first CF mouse models were generated. The CF mouse models generated to date have …

… Most cystic fibrosis (CF) patients produce a mutant form (AF508) of the cystic fibrosis … We
used a double homologous recombination ('Hit and Run') procedure to generate a mouse …

… cystic fibrosis (CF) alleles on cholera toxin (CT)-induced intestinal secretion was examined
in the CF mouse … Cystic fibrosis homozygotes treated identically had no response. Intestinal …

… is a mutation that deletes phenylalanine 508 in cystic fibrosis transmembrane conductance
… Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model. …

… The CFTR null mouse [cystic fibrosis (CF) mouse] has a severe … investigate gene expression
in the CF mouse small intestine. Sixty-… cystic fibrosis (CF) is an autosomal recessive disease …