Signal transduction in atherosclerosis: integration of cytokines and the eicosanoid network

DP Hajjar, KB Pomerantz - The FASEB journal, 1992 - Wiley Online Library
Atherosclerosis can be defined in broad terms as a vascular … : 1) inflammation resulting in
release of cytokines, 2) changes in … that eicosanoids and cytokines released from one cell …

Mast cells promote atherosclerosis by releasing proinflammatory cytokines

J Sun, GK Sukhova, PJ Wolters, M Yang, S Kitamoto… - Nature medicine, 2007 - nature.com
… Yet the cellular source of cytokines can influence their function decisively. For example, …
cell–derived proinflammatory cytokines may be critical in promoting atherosclerosis. To test this …

Possible role of parathyroid hormone–related protein as a proinflammatory cytokine in atherosclerosis

JL Martín-Ventura, M Ortego, P Esbrit… - Stroke, 2003 - Am Heart Assoc
… We examined the possible role of PTHrP in the inflammatory process in atherosclerosis
effects of statins in atherosclerosis. The pathophysiological aspects of atherosclerosis include an …

Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines

J Frostegård, AK Ulfgren, P Nyberg, U Hedin… - Atherosclerosis, 1999 - Elsevier
… production of IL-12 [19] suggests that the Th1 pathway may dominate in atherosclerosis. …
for cytokine transcripts and proteins, we show a pro-inflammatory, Th1-type cytokine secretory …

A perspective on targeting inflammation and cytokine actions in atherosclerosis

YH Chan, DP Ramji - Future medicinal chemistry, 2020 - Taylor & Francis
Atherosclerosis, a chronic inflammatory disorder of the … that inhibition of a specific proinflammatory
cytokine (IL-1β) yielded … on targeting inflammation for atherosclerosis, focusing on …

Circulating markers of inflammation and atherosclerosis

L Lind - Atherosclerosis, 2003 - Elsevier
… TNF-α plays a major role in the cytokine cascade as it stimulates the synthesis of … cytokines.
Also the other two pro-inflammatory cytokines, interleukin-1 and -6, are pleotropic cytokines

Atherosclerosis and immunity: a perspective

F Abdolmaleki, SMG Hayat, V Bianconi… - Trends in cardiovascular …, 2019 - Elsevier
Atherosclerosis is an inflammatory and multifaceted disorder … subtypes, which is influenced
by cytokines, mediators, and … , are involved in atherosclerosis progression and there is an …

Pathogenesis of atherosclerosis

MA Crowther - ASH Education Program Book, 2005 - ashpublications.org
… Recruited macrophages both release additional cytokines and begin to migrate through the
… monocytes leads to both cytokine-mediated progression of atherosclerosis, and oxidation of …

Accelerated atherosclerosis in systemic lupus erythematosus: role of proinflammatory cytokines and therapeutic approaches

C Lopez-Pedrera, MA Aguirre… - BioMed Research …, 2010 - Wiley Online Library
… to the inflammatory cytokine-dependent response in the vessel wall by production of
cytokines or eliciting responses to cytokines, or can be involved in cytokine-mediated interaction …

Interleukin-18: a potent pro-inflammatory cytokine in atherosclerosis: EXPERT'S PERSPECTIVE

L Badimon - Cardiovascular research, 2012 - academic.oup.com
… of this cytokine, widely studied in other types of inflammatory diseases, in atherosclerosis. …
Next, studies in Apo E −/− mice showed that IL-18 administration enhanced atherosclerosis