… of a dimeric peptide–MHC class II–IgG chimera to bind to and activate cognate T cell lines…
We found that, in contrast to monomeric peptide–MHC class II, the dimeric peptide–MHC …

… MHC binding was measured concurrently with several T cell activation processes, using …
dimer of MHC-peptide complexes is necessary and sufficient for initiation of T cell activation. …

… The dimer therapy resulted in the activation and increased cell death of transferred BDC2.5 …
T cells, we produced dimers of soluble peptide IA g7 in which the BDC2.5 mimotope peptide …

… vasopressin receptor in COS-7 cells. In order to determine the functional correlate of receptor
dimerization, we measured the effect of disrupting dimerization on the ability of the receptor …

… agonist peptide (SIY) in the context of K b (16). The addition of peptide dimer to 2C T cell
cultures … Early activation events were induced by MHC dimer engagement of TCR, including up-…

… experiments, we describe a dimeric binding mode in which two T cell receptors engage in an
anti-… that pMHC dimers containing one agonist and one null ligand efficiently activate CTL, …

… We have also tested the formation of peptide dimers in solution by analytical ultracentrifugation
and find that the EMP33 and EMP1 form homodimers with similar dissociation constants (…

… cell surface-expressed disulfide-linked dimer that has a mw of 85,000 under non-reducing
conditions and consists of subunits of 35,000 to 39,000 mw This dimer … gle-peptide backbone …

… that dimerization of Stat91 is mediated through SHP-phosphotyrosyl peptide interactions. …
This peptide showed no effect on the Stat91 dimer formation (Figure 48, lane 11-13). Thus, …

… by autoreactive T cells. We show here that administration of a soluble dimeric peptide–major …
ZAP-70 is critical for productive T cell activation 52 and is negatively regulated in T cells …