… Polypharmacology and chemical biology studies are amassing interaction data at rapid rates,
… recent developments in systems-level research for drug design and discovery, and discuss …

… Accordingly, the stage has been set for a shift to a systems-level perspective. This shift has
been catalyzed by new technology and methods in systems and chemical biology that aim to …

… Modern chemical biology and drug discovery each seek to identify new small molecules
that potently and selectively modulate the functions of target proteins. Historically, nature has …

Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling
protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are …

… chemical biology, in particular synthesis of peptides and peptidomimetics for probing
biological … to address long-standing problems in Chemical Biology. Her research efforts aim at …

… The discovery of new molecules for modulating biological function is a key motivation in
chemical biology and the primary focus in drug discovery programs. Over the past two decades, …

… drug discovery pipelines; but screening was still in the setting of complex disease biology, …
or indirectly from such early 'systems biology'-based drug discovery. In the interest of speed …

… in chemical biology and drug discovery. Here we review the state of the field in the context
of harnessing chirality as a source of chemical information at the chemistry-biology interface. …

… This genomics-driven discovery of new chemical entities is a key, first step in
understanding the specialized chemical biology of these important planktonic organisms. The …

… biology and discuss how this emerging discipline could facilitate a systems approach to
drug discovery, … , provide a template for systems modeling of drug discovery, by integrating …