… representative cases of molecular glues and analyzes the binding mode of the molecular
glue–protein complex. Based on the aggregation mode of molecular glues mediating protein–…

… target could be bound/glued by multiple MG compounds with … generate various molecular
gluing tools for disease mechanism … for the treatment of various types of human diseases, …

… We also outline the advantages of the molecular glues and summarize the advances in …
progression of molecular glues in drug discovery pipelines and their targeted diseases. Overall, …

… The concept of protein degradation is concerned with molecular glues, which form part of
the broader field of Targeted Protein Degradation (TPD). Next, pharmacochemical strategies …

… small molecule drugs have been successfully used as treatments for decades, tackling a
variety of disease-… small-molecule inhibitors. To pursue this strategy, heterobifunctional small …

… to our armamentarium to treat diseases like cancer and neurodegeneration. However,
despite this impressive progress, the de-novo development of a molecular glue is a tremendous …

… used in the clinic and are a class of molecular glue that induces degradation of several neo-…
of molecular glues and share our opinions on the identification of novel molecular glues in …

… activity can target disease. However, while non-native degradation is the current research
focus, type III molecular glues have also been shown to alleviate disease phenotypes by …

… molecule … molecular glues are not tied to the dose of these molecular entities but to the
formation of the ternary complex. Here, we provide an overview of PROTACs and molecular glues …

… molecular glue refers to a small molecule that sticks two proteins together. The most common
type links a target protein-typically one that causes disease-… In the body, the glue molecule …