Dynamics of DNA methylation in aging and Alzheimer's disease

HA Irier, P Jin - DNA and cell biology, 2012 - liebertpub.com
… of DNA methylation in neurodegenerative diseases, with a special focus on DNA methylation
… context of neurodegeneration and its potential role in aging and Alzheimer's disease (AD). …

DNA methylation variability in Alzheimer's disease

Z Huo, Y Zhu, L Yu, J Yang, P De Jager, DA Bennett… - … of Aging, 2019 - Elsevier
DNA methylation plays a critical role in brain aging and Alzheimer's disease (AD). While …
largely focused on testing mean DNA methylation, DNA methylation instability (quantified by …

[HTML][HTML] A meta-analysis of brain DNA methylation across sex, age, and Alzheimer's disease points for accelerated epigenetic aging in neurodegeneration

C Pellegrini, C Pirazzini, C Sala, L Sambati… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

[HTML][HTML] Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease

DL McCartney, AJ Stevenson, RM Walker… - Alzheimer's & Dementia …, 2018 - Elsevier
of ageing and may be predictive of age-related disorders, … related outcomes, including
Alzheimer's disease pathology and … In this study, we present the largest study of DNA methylation–…

DNA methylation in Alzheimer's disease: In brain and peripheral blood

X Wei, L Zhang, Y Zeng - Mechanisms of Ageing and Development, 2020 - Elsevier
Alzheimer's disease (AD) is the most widespread neurodegenerative disorder and has …
on DNA methylation in brain cortexes as well as in peripheral blood of AD patients expecting to …

[HTML][HTML] Common DNA methylation alterations of Alzheimer's disease and aging in peripheral whole blood

H Li, Z Guo, Y Guo, M Li, H Yan, J Cheng, C Wang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a common aging-related neurodegenerative illness. Recently,
many studies have tried to identify AD- or aging-related DNA methylation (… showed that aging-…

DNA methylation in the pathology of Alzheimer's disease: from gene to cognition

CH Poon, LSR Tse, LW Lim - Annals of the New York Academy …, 2020 - Wiley Online Library
… of DNA methylation, the effects of aberrant methylation on gene … , as well as memory
epigenetics in Alzheimer's disease. … investigated regarding its association with aging, memory, …

DNA methylation and Alzheimer's disease

T van Groen - Epigenetics of aging, 2010 - Springer
… in the chances of developing Alzheimer’s disease. The decreased DNA methylation status
with … genes show similar decreased promoter methylation with aging, causing higher levels – …

Epigenetics in Alzheimer's disease: perspective of DNA methylation

TJ Qazi, Z Quan, A Mir, H Qing - Molecular Neurobiology, 2018 - Springer
… the cellular aging process, as shown by DNA hypomethylation, … Most aging studies have
focused on DNA methylation for the … in children and with aging [38]. Certain loci have a strong …

Epigenetic changes in Alzheimer's disease: decrements in DNA methylation

D Mastroeni, A Grover, E Delvaux, C Whiteside… - … of aging, 2010 - Elsevier
DNA methylation is a vital component of the … DNA methylation and eight methylation
maintenance factors in entorhinal cortex layer II, a region exhibiting substantial Alzheimer's disease (…