DNA methylation in health and disease

KD Robertson, AP Wolffe - Nature reviews genetics, 2000 - nature.com
… In this article, we first summarize the basics of DNA methylation in the genome and … methylation
machinery and its role in development. We also discuss the functions of DNA methylation

DNA methylation in health, disease, and cancer

DS Shames, JD Minna… - Current molecular …, 2007 - ingentaconnect.com
… The major focus of this review involves DNA methylation and its role in cancer development.
However, the influence of histones and their modifications, as well as the PcgTrxG proteins …

DNA methylation, early life environment, and health outcomes

C Mitchell, LM Schneper, DA Notterman - Pediatric research, 2016 - nature.com
… environment can affect health. Strong evidence … health, wellbeing, and behavior (2,3,4).
This review describes some of the recent work in this area, but first reviews DNA methylation (its …

DNA methylation dynamics in health and disease

Y Bergman, H Cedar - Nature structural & molecular biology, 2013 - nature.com
DNA methylation is an epigenetic mark that is erased in the early embryo and then re-established
at the time of implantation. In this Review, dynamics of DNA methylationmethylation

DNA methylation 40 years later: Its role in human health and disease

MI Scarano, M Strazzullo, MR Matarazzo… - Journal of cellular …, 2005 - Wiley Online Library
… Here, we review the impact of the studies on DNA methylation, the “primadonna” in the …
The effect of deregulation of DNA methylation on human health, will be also discussed. …

DNA methylation and regulation of gene expression: Guardian of our health

GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
… As discussed earlier, DNA methylation is a critical parameter affecting our health and well-being.
The current review primarily aims to bring a holistic picture of the crosstalk between …

Insufficient DNA methylation affects healthy aging and promotes age-related health problems

L Liu, T Van Groen, I Kadish, Y Li, D Wang… - Clinical …, 2011 - Springer
… and other health conditions during the aging process. Our results clearly support the likelihood
that insufficient DNA methylation can lead to early onset of sub-optimal health conditions …

A systematic review and meta-analysis of environmental, lifestyle, and health factors associated with DNA methylation age

J Ryan, J Wrigglesworth, J Loong… - The Journals of …, 2020 - academic.oup.com
DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an
individual’s chronological age and can predict their risk of age-related disease and mortality. This …

DNA methylation-based predictors of health: applications and statistical considerations

PD Yousefi, M Suderman, R Langdon… - Nature Reviews …, 2022 - nature.com
… to the development of DNA methylation-based predictors across a wide range of health-related …
This Review evaluates the progress of existing DNA methylation-based predictors, …

Impact of DNA methylation on health and disease

M Esteller - DNA Methylation: Approaches, Methods, and …, 2005 - books.google.com
… Chapter 3 reflects the relevance of DNA methylation to the control of gene imprinting and
X inactivation. In summary, the disruption of DNA methylation patterns is a major hallmark of …