DNA methylation in the pathology of Alzheimer's disease: from gene to cognition
… However, there are still huge research gaps regarding the DNA methylation status of
confirmed risk gene loci. Future research focused on elucidating the epigenetic status of these …
confirmed risk gene loci. Future research focused on elucidating the epigenetic status of these …
DNA methylation variability in Alzheimer's disease
… and Alzheimer's disease (AD). While prior studies have largely focused on testing mean
DNA methylation, DNA methylation instability (… GWAS loci enrichment is shown in Table S8. …
DNA methylation, DNA methylation instability (… GWAS loci enrichment is shown in Table S8. …
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
… We found that the level of methylation at 71 of the 415,848 … We validated 11 of the differentially
methylated regions in an … Our analyses suggest that these DNA methylation changes …
methylated regions in an … Our analyses suggest that these DNA methylation changes …
DNA methylation in Alzheimer's disease: In brain and peripheral blood
X Wei, L Zhang, Y Zeng - Mechanisms of Ageing and Development, 2020 - Elsevier
… Alzheimer's disease (AD) is the most widespread neurodegenerative … methylated loci (DMLs)
or differentially hydro-methylated loci (DhMLs). With the development of DNA methylation …
or differentially hydro-methylated loci (DhMLs). With the development of DNA methylation …
Association of peripheral blood DNA methylation level with Alzheimer's disease progression
…, Alzheimer's Disease Neuroimaging Initiative (ADNI) - Clinical …, 2021 - Springer
… 0.98, P < 2.2e −16 ) and hence a methylation quantitative trait locus (mQTL) in cis (Fig. 1C), …
, logical memory delayed recall, Alzheimer Disease Assessment Scale-Cognitive Subscale …
, logical memory delayed recall, Alzheimer Disease Assessment Scale-Cognitive Subscale …
Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease
… methylation was located preferentially within AD risk loci from … of differentially methylated
sites were present in AD risk loci (… to the background overlap with risk loci (562/419,432, 0.13%; …
sites were present in AD risk loci (… to the background overlap with risk loci (562/419,432, 0.13%; …
[PDF][PDF] DNA methylation alterations in Alzheimer's disease
AS Yokoyama, JC Rutledge… - Environmental epigenetics, 2017 - academic.oup.com
… 28 gene loci associated with AD pathology. Of the 28 gene loci, DNA methylation of five genes
… Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. …
… Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. …
Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease
…, Alzheimer's Disease Neuroimaging Initiative (ADNI) - Clinical …, 2020 - Springer
… d Distribution of differential DNA methylation marks across different genomic loci. … Data
collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging …
collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging …
Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease
… in DNA methylation in the superior temporal gyrus of patients with Alzheimer’s disease,
highlighting novel loci that … and mechanisms underlying Alzheimer’s disease pathogenesis, and …
highlighting novel loci that … and mechanisms underlying Alzheimer’s disease pathogenesis, and …
DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain
M Barrachina, I Ferrer - Journal of Neuropathology & …, 2009 - academic.oup.com
… and for aberrant DNA in cancer. To determine the feasibility of DNA methylation studies in
the … The global DNA methylation profile for these 2 loci is similar to that observed in the 5′ …
the … The global DNA methylation profile for these 2 loci is similar to that observed in the 5′ …
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