… Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells (PGCs)
and preimplantation embryos, but the precise dynamics and biological outcomes are …

… Genome-wide DNA methylation profiling reveals that PGCs undergo DNA demethylation
in two distinct phases [86,87] (Figure 4). The first phase, starting at ~E8.5, occurs during …

… In addition, a number of studies have investigated the role of several factors that play a role
in DNA methylation erasure in the early embryo and PGCs, further adding to our mechanistic …

… Here we give a snapshot of the current understanding of epigenetic dynamics during the
mammalian life cycle, with a focus on DNA methylation and genomic imprinting of PGCs and …

… affects the DNA methylation reprogramming of PGCs. In this study, … assessed DNA methylation
reprogramming in male PGCs … that early epigenetic reprogramming in PGCs was altered …

… Our basic understanding of mammalian PGC specification and epigenetic reprogramming
stems largely from work in the mouse. However, recent work is beginning to shed light on …

… germ cells (PGCs) activates epigenetic reprogramming for … for DNA methylation reprogramming
during in vitro PGC … epiblast-like cells (EpiLCs) and then PGC-like cells (PGCLCs). While …

… , in methylation … in reprogramming in PGCs, but the process in its entirety is still poorly
understood. In this review, we discuss the dynamics of DNA methylation reprogramming in PGCs …

… to investigate DNA methylation reprogramming during … (PGCs) undergo significant DNA
methylation reprogramming during germ cell development, and the methylome of PGCs is reset …

… if this stepwise loss of DNA demethylation in PGCs is linked to … PGCs and somatic cells
between 9.5 dpc and 13.5 dpc (see also [5] for L1). In early PGCs (9.5 dpc) DNA methylation was …