… DNA methylation states, we used mouse embryonic stem cells as a cellular model. The
methylation … epiblast cells, with established genome-wide methylation outside of CpG islands 24 . …

… acquisition of DNA methylation upon binding of a TF to unmethylated DNA, (b) promotion of
DNA methylation upon binding of a TF to unmethylated DNA, (c) reversal of DNA methylation …

… methylation states and compared the model to existing imputation strategies for DNA
methylation … , we considered local averaging of the observed methylation states, either in 3-kbp …

… Interestingly, CGIs marked by H3K27me3 are nevertheless more susceptible to DNA
methylation during differentiation and in disease states such as cancer 46,47 . Furthermore, CGIs …

… Although of vital importance for the DNA methylation process in cells, this preference is by
far not enough to copy faithfully and site specifically the methylation state of the ∼56 million …

… Since that time, bisulphite genomic sequencing has become the standard for DNA methylation
analysis, as this method defines the methylation state of every cytosine residue in the …

… , DNA methylation at cis-regulatory sequences determines whether gene expression is on or
off. Stable inheritance of these expression states is … the stability of these states by using the …

… MethylMix requires a large cohort to identify methylation states and capture DNA methylation
heterogeneity present in a particular disease. We used MethylMix and their associated DM-…

… To further evaluate the effectiveness of DeepSignal for predicting DNA methylation state,
we compare it with the results of bisulfite sequencing of two H. sapiens samples: HX1 and …

… , the inheritance of these DNA methylation states has been … methylation state of a single
CpG site (12,13). Because unmethylated cytosine is inserted into the new strands during DNA …