… With the model being internally and externally validated, a new dosing regimen will be
proposed based on the model. In this fourth step, data simulation is a helpful tool. Here, the …

… and dosing regimen. In this perspective we consider that dose ranging and dose selection in
… The pharmacokinetic model that describes our gentamicin-like drug at a specific time (t) is: …

… However, an increasing number of simulation studies using population PK models show
that a dosing regimen of 1200 mg/day is necessary to attain the pharmacodynamic target of …

… Data from a typical population pharmacokinetics study consist of the dosing histories and
concentration/time data from a number of individuals. Patient-specific characteristics (covariates…

… Model-based simulations were used to compare the adequacy of different dosage regimens
in relation to the … In conclusion, the population approach is very useful to characterize the …

… This article provides the pharmacokinetic (PK) rationale for the dosing regimens that were …
doses and the use of paliperidone palmitate in special patient populations is also discussed. …

… dosage regimen and dosing interval of new inhaled drugs, in this study we investigated the
lung pharmacokinetics (PK… limitations of studying lung pharmacokinetics in isolated, perfused …

… population. Our objectives were to describe population PK and optimized dosing regimens
for … Furthermore, we sought to externally validate the model as well as quantify the value of …

… pediatric population. In this study, both neonatal and pediatric pharmacokinetic models for
vancomycin were externally evaluated and subsequently used to derive model-based dosing …

… two clinical efficacy trials were used to develop a population model of the pharmacokinetics
of intravenous (iv) ciprofloxacin. Dosage regimens ranged between 200 mg every 12 h and …