Modeling drug passage into human milk

PO Anderson, JB Sauberan - Clinical Pharmacology & …, 2016 - Wiley Online Library
human studies can reliably quantify drug passage into breastmilk. The standard method of
quantifying drug passage into breastmilk is the administration of a drug … she is taking the drug

Non-clinical models to determine drug passage into human breast milk

D Ventrella, M Forni, ML Bacci… - Current Pharmaceutical …, 2019 - ingentaconnect.com
drug passage into human milk’, ie. assessment or prediction of (variability of) drug
concentration-time profiles in human milk … nursing infants during maternal drug therapy. In this …

[HTML][HTML] Drug distribution in human milk

KF Ilett, JH Kristensen… - Australian …, 1997 - australianprescriber.tg.org.au
… The distribution of drugs and environmental chemicals into human milk continues to be an
drugs are considered safe. The passage of low molecular weight heparin into human milk

Models and methods for predicting drug transfer into human milk

JC Fleishaker - Advanced drug delivery reviews, 2003 - Elsevier
… for predicting drug transfer into milk in humans. These … that control drug partitioning between
milk and plasma. In vivo … that may either transport drugs into or out of breast milk. Finally, …

[HTML][HTML] A comprehensive review on non-clinical methods to study transfer of medication into breast milk–A contribution from the ConcePTION project

N Nauwelaerts, N Deferm, A Smits, C Bernardini… - Biomedicine & …, 2021 - Elsevier
… transfer of medication into the human milk. However, reliable … in culture for at least 15 passages
and could represent a good … often applied to predict drug-drug interactions and to select …

Developing an in vitro to in vivo extrapolation (IVIVE) model to predict human milk-to-plasma drug concentration ratios

H Yang, I Xue, Q Gu, P Zou, T Zhang, Y Lu… - Molecular …, 2022 - ACS Publications
… Determining the amount of drug transferred into human milk is critical for benefit–risk analysis
… pH of human milk during lactation, we conducted a sensitivity analysis by setting milk pH at …

Drugs and chemical contaminants in human breast milk

A Anadón, MR Martínez-Larrañaga, I Ares… - Reproductive and …, 2017 - Elsevier
… serum protein may contribute to drug excretion into human milk. The nonionized fraction of
any … Because the blood–brain barrier (BBB) is not fully developed in neonates, drug passage

Prediction of drug distribution into human milk from physicochemical characteristics

UC Atkinson, EJ Begg - Clinical pharmacokinetics, 1990 - Springer
… Steady-State Assumptions These models all assume that the rate of drug passage across
the membrane between milk and pl:lsma is relallvely rapid and that equilibrium be· tween …

Drugs and chemicals in human milk

CM Berlin, GG Briggs - Seminars in Fetal and Neonatal Medicine, 2005 - Elsevier
… Most drugs and many chemicals will be transferred into milk. … of the transfer of drugs into
milk, discusses the importance of the … of maternal conditions for which drugs need to be used. …

Selective serotonin reuptake inhibitors' passage into human milk of lactating women

L Pogliani, S Baldelli, D Cattaneo, P Pileri… - The Journal of …, 2019 - Taylor & Francis
… the passage of these drugs into human milk, often with conflicting results. Here, we sought
to evaluate the passage of selective serotonin reuptake inhibitors into human milk in the first …