… to be an important source of cancer cells that eventually acquire irreversible resistance. …
mechanisms of drug tolerance of EGFR-mutated lung cancers employ lung cancer cell lines as …

… In this review, we discuss how lung cancer cells become resistant or tolerant to targeted …
of drug-tolerant persister (DTP) cells and the mechanistic basis of drug tolerance in EGFR-…

… signaling pathways in intestines and gastric cancer (31), we hypothesized that ACh signaling
may regulate the emergence of drug tolerance, potentially by activating WNT signaling. …

… of EGFR TKI drug tolerance To identify proteins that affect drug tolerance for EGFR TKIs, we
… the screen in parallel using two human lung adenocarcinoma cell lines, PC9 and HCC827. …

… drug resistance in lung cancer is shown here as an example. There are two recognized
models of mechanisms of drug … behind minimal residual disease and drug tolerance-resistance …

… if all EGFR-mutated lung cancers use the same molecular mechanisms to survive as DTCs,
we hypothesized that novel molecular mechanisms of drug tolerance may be identified if we …

… response in non–small cell lung cancer (NSCLC) patients with … to conquer ALK-positive lung
cancer. We established three … had cancer stem cell-like (CSC) properties, suggesting drug-…

… Using a selected array of drugs based on the first screen, we … effectiveness of these drugs
in another lung cancer model, the … drugs clinically approved for the treatment of lung cancer, …

… Other metabolic pathways are involved in drug tolerance, as demonstrated in lung cancer
… -147b and EGFR delays the emergence of drug tolerance in lung cancer PDX model (134). …

… from a single, EGFR-addicted lung cancer cell. We find, using a combination of large-scale …
compelling evidence of transformation to small cell lung cancer, epithelial-to-mesenchymal …