… to study sepsis and new therapeutic approaches for sepsis, … promising new compounds for
sepsis have been developed. In … vasodilation in sepsis [14] , this new therapeutic approach is …

… However, we suggest that a greater impediment to success in sepsis treatment is the lack
of effective host-directed therapies. To promote the development of innovative therapies, …

… therapeutic approach to sepsis. Some obvious questions come to mind. First, is the current
understanding of the pathophysiology of sepsis … evaluation of potential therapies in need of …

… necessary to ultimately determine whether endotoxin is an effective therapeutic target in
sepsis. … will be essential to designing and testing more effective therapeutic strategies in sepsis. …

… sepsis remains the mainstay of therapy for severe sepsis. How these new and often expensive
regimens will fit into the standard treatment approach to sepsis … relevant or cost effective. …

… Abscesses present a series of barriers to effective therapy; antimicrobials cannot be effectively
delivered into the avascular core of abscesses or other necrotic tissue (depending on size)…

… The effects of steroids on the relative survival benefit in the nine sepsis trials of high-dose
steroids … decrease in the relative survival benefit with steroid therapy during sepsis (p =0.008). …

… agonist to antagonist, for modulators of sepsis that protect from tissue damage while allowing
antimicrobial defense, and for effective therapies impacting the end organ damage of the …

… that we reconsider our approach to therapy for sepsis. … Furthermore, an animal model of
sepsis shows that therapy … is far more effective in preventing death than any one therapy or …

… have the most favourable cost-effectiveness ratio. In this article, … sepsis therapies,
including a review of the costs of sepsis, new anti-sepsis strategies, and elements of cost-effectiveness …