This study represents the synthetic approaches of a new set of 2-(((3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazono)-5-(aryl)thiazolidin-4-one
derivatives 4–22 …

… Once again, the 2,4-dinitrophenyl-hydrazono-thiazolidin-4-one derivatives 5f and 5e were
the most potent derivatives, with IC 50 values of 87 and 93 nM, respectively. Based on the …

… -target inhibitors, dual inhibitors targeting both the EGFR … EGFR and BRAF inhibition has
resulted in synergistic antitumor effects in preclinical studies [13]. Furthermore, dual inhibitors …

… Furthermore, thiazole and thiazolidine pharmacophores occupy an important place in the
field of anticancer chemotherapy targeting different proteinsCitation 40–42 . Pyrazolyl-thiazole …

… Our strategy started by the previously prepared key (pyridin-2-yl)ethylidene)hydrazono)-thiazolidin-4-one
derivative 1 for the preparation of different N-substituted glycopyranosyl …

… cm −1 representing NH groups of the hydrazono linker. Furthermore, 1 H NMR chemical …
-CH 3 group, the methine proton of the hydrazono CH = N group was represented as a singlet …

… , we report herein the design and synthesis of a series of potential EGFR inhibitors based on
… In the second series bearing a phenyl group in the thiazolidine ring, compound 5h with an …

… derivatives 1 and 2 with N-substituted thiosemicarbazides to afford the corresponding
thiosemicarbazones 3–6 that were cyclized using ethyl bromoacetate to provide thiazolidin-4-one …

… As a result, inhibiting the two kinases sequentially may address the issue of EGFR activation…
for the methyl group at position four of the thiazolidine ring moiety, indicating that the phenyl …

Motivated by the potential anticancer activity of both coumarin and 2-aminothiazole nuclei, a
new set of thiazol-2-yl hydrazono-chromen-2-one analogs were efficiently synthesized …