Engineering antigen-specific immunological tolerance
S Kontos, AJ Grimm, JA Hubbell - Current opinion in immunology, 2015 - Elsevier
… review is on antigen-specific tolerance — where immune responses to specific antigens are
… below particularly noteworthy advances in antigen-nonspecific approaches, considering …
… below particularly noteworthy advances in antigen-nonspecific approaches, considering …
[PDF][PDF] Engineering tolerance using biomaterials to target and control antigen presenting cells
LH Tostanoski, EA Gosselin, CM Jewell - Discov. Med, 2016 - jewell.umd.edu
… to APCs, ii) biomaterial-mediated control over antigen localization and processing, and iii) …
gies to promote tolerance by altering the trafficking or processing of these self-antigens. …
gies to promote tolerance by altering the trafficking or processing of these self-antigens. …
Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance
… antigens, data from preclinical models show that donor-reactive Tregs are more effective
than polyclonal Tregs in promoting transplant tolerance (6)… or chimeric antigen receptors (CAR) …
than polyclonal Tregs in promoting transplant tolerance (6)… or chimeric antigen receptors (CAR) …
Engineering immunological tolerance using quantum dots to tune the density of self‐antigen display
KL Hess, E Oh, LH Tostanoski… - Advanced functional …, 2017 - Wiley Online Library
… or tolerance is influenced by the form in which self-antigens … immunological tolerance by
controlling the density of self-antigen … scavenger receptors involved in tolerance. Treatment with …
controlling the density of self-antigen … scavenger receptors involved in tolerance. Treatment with …
Engineered tolerance: tailoring development, function, and antigen-specificity of regulatory T cells
… Here, we review cell and protein engineering-based approaches that aim to target different
… targeted antigen-specificity using transgenic T cell receptors or chimeric antigen receptors. …
… targeted antigen-specificity using transgenic T cell receptors or chimeric antigen receptors. …
Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes
N Pishesha, T Harmand, LY Smeding, W Ma… - … Engineering, 2021 - nature.com
… Because antigen-presenting cells are tolerogenic when they … antigen under non-inflammatory
conditions, the manipulation of antigen presentation may induce antigen-specific tolerance…
conditions, the manipulation of antigen presentation may induce antigen-specific tolerance…
Engineering immune tolerance with biomaterials
… with regulatory cues as therapeutic vaccine that could induce antigen-specific tolerance. …
the exciting potential for engineering biomaterials that promote tolerance that is safer, more …
the exciting potential for engineering biomaterials that promote tolerance that is safer, more …
Epitope-specific tolerance induction with an engineered immunoglobulin.
ET Zambidis, DW Scott - Proceedings of the National …, 1996 - National Acad Sciences
… consisting ofa recombinantflagellin challenge antigen and a murine … whole antigens by
selecting epitopes for either tolerance or … Protein engineering strategies have been used to create …
selecting epitopes for either tolerance or … Protein engineering strategies have been used to create …
Engineering antigen-specific tolerance to an artificial protein hydrogel
PB Rapp, JA Baccile, RP Galimidi… - … Science & Engineering, 2024 - ACS Publications
… antigens to the correct immunological address could induce this desirable immune phenotype.
… of a broadly applicable approach for inducing antigen-specific tolerance to protein-based …
… of a broadly applicable approach for inducing antigen-specific tolerance to protein-based …
[HTML][HTML] T cells expressing chimeric antigen receptor promote immune tolerance
A Pierini, BP Iliopoulou, H Peiris, M Pérez-Cruz… - JCI insight, 2017 - ncbi.nlm.nih.gov
… genetic engineering to permit expression of a CAR in Tcons and Tregs that bind antibodies
… homing of T cells expressing mAbCAR to specific antigens and cells. We used the mAbCAR …
… homing of T cells expressing mAbCAR to specific antigens and cells. We used the mAbCAR …
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