… prostate cancer. It persists to attract much scientific attention due to its important role in the
process of cancer … Thus here we review the dysregulation of EZH2 in prostate cancer, its …

… Epigenetic mechanisms may be the main driving force for critical changes in gene … of
prostate cancers. The three most extensively characterized mechanisms for epigenetic gene…

We report a novel computational method, RegNetDriver, to identify tumorigenic drivers using
the combined effects of coding and non-coding single nucleotide variants, structural variants…

… epigenetic dysregulation is a plausible driving mechanism in the reprograming of prostate
cancer … Beyond reviewing the current status of epigenetic biomarkers and classifiers and their …

… and cancer progression 1,2,3 . Characterizing the epigenetic determinants driving gene …
We sought to determine how the epigenetic landscape of prostate tumors reflects and …

… As AR—the main driver of prostate cancer—functions in conjunction with chromatin
modifications to control transcription, we set out to comprehensively profile 100 primary …

… drivers of prostate cancer, some of which are not associated with permanent DNA changes,
but with epigenetic … epigenetic machinery in regulating the development and progression of …

… For instance, the histone dimethyl methyltransferase WHSC1 (also known as NSD2) was
found to be stabilized by AKT and its stabilization plays a causal role in driving prostate cancer …

… with CA21 which further indicates epigenetic variation among races. The availability of
only … in our understanding of the global epigenetic factors driving racial disparity.22-27 …

… Second, in prostate cancer, a cancer type with few recurrently mutated genes, we
demonstrate how the epigenome primes tumours towards higher tolerance of other aberrations. …