The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment
JE Trosko, BL Upham - Mutagenesis, 2005 - academic.oup.com
… We focus on the often ignored ‘epigenetic’ effects of carcinogens … intracellular signaling
and alter gap junctional intercellular … ) Epigenetic toxicity of a mixture of polycyclic aromatic …
and alter gap junctional intercellular … ) Epigenetic toxicity of a mixture of polycyclic aromatic …
Novel regulator role of CIL-102 in the epigenetic modification of TNFR1/TRAIL to induce cell apoptosis in human gastric cancer
CC Teng, SY Tung, KC Lee, KF Lee, WS Huang… - … Chemical Toxicology, 2021 - Elsevier
… Moreover, our data revealed that multiple signaling pathways were involved in the H3K4
trimethylation of TNFR1 and TRAIL proteins by CIL-102, including ROS-derived and JNK/mTOR/…
trimethylation of TNFR1 and TRAIL proteins by CIL-102, including ROS-derived and JNK/mTOR/…
Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms
L Ou, B Song, H Liang, J Liu, X Feng, B Deng… - … and fibre toxicology, 2016 - Springer
… The toxicological mechanisms of GFNs … signalling pathways network regulating the toxicity
of GFNs. It needs to point out that there are several factors which largely influence the toxicity …
of GFNs. It needs to point out that there are several factors which largely influence the toxicity …
Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis
R Terranova, A Vitobello, ADR Espinola… - … Opinion in Toxicology, 2017 - Elsevier
… Enhancers are bound by regulatory transcription factors and integrate extracellular signalling
pathways with intracellular cell fate information to elicit cell type-specific transcriptional …
pathways with intracellular cell fate information to elicit cell type-specific transcriptional …
… pyrrolidone-coated silver nanoparticles in a human lung cancer cells: Time-and dose-dependent influence over p53 and caspase-3 protein expression and epigenetic …
J Blanco, D Lafuente, M Gómez, T García… - … of toxicology, 2017 - Springer
The present study was aimed at providing a better understanding of the influence of silver
nanoparticles (AgNPs) on the p53 tumor suppressor protein. Cell line A549 was exposed to a …
nanoparticles (AgNPs) on the p53 tumor suppressor protein. Cell line A549 was exposed to a …
Progress of signaling pathways, stress pathways and epigenetics in the pathogenesis of skeletal fluorosis
L Qiao, X Liu, Y He, J Zhang, H Huang, W Bian… - International journal of …, 2021 - mdpi.com
… Signaling pathways, stress pathways, epigenetics, and … medicine aims to reduce the toxicity
of fluoride to the body and … magnesium can antagonize fluoride toxicity by binding fluoride …
of fluoride to the body and … magnesium can antagonize fluoride toxicity by binding fluoride …
Nickel: Human health and environmental toxicology
G Genchi, A Carocci, G Lauria, MS Sinicropi… - International journal of …, 2020 - mdpi.com
… toxicity of this metal. Recently, researchers, trying to characterize the capability of nickel to
induce cancer, have found out that epigenetic … The former is activated by intracellular signals …
induce cancer, have found out that epigenetic … The former is activated by intracellular signals …
Oxidative stress and its role in Cd-induced epigenetic modifications: use of antioxidants as a possible preventive strategy
EY Hernández-Cruz, YL Arancibia-Hernández… - Oxygen, 2022 - mdpi.com
… Oxidative stress (OS) represents one of the main mechanisms of toxicity induced by …
increases ROS production by triggering increased extracellular signal-regulated kinases (ERK), …
increases ROS production by triggering increased extracellular signal-regulated kinases (ERK), …
Disruption of gap junctions in toxicity and carcinogenicity
JK Chipman, A Mally, GO Edwards - Toxicological Sciences, 2003 - academic.oup.com
… to play a role in channel gating and intracellular signaling, and they vary between members
of the … Epigenetic toxicology as toxicant-induced changes in intracellular signaling leading to …
of the … Epigenetic toxicology as toxicant-induced changes in intracellular signaling leading to …
Nanomaterial and toxicity: what can proteomics tell us about the nanotoxicology?
D Nath Roy, R Goswami, A Pal - Xenobiotica, 2017 - Taylor & Francis
… In this study, some proteins like cadherin 1 (CDH1), signal transducer and activator of …
Epigenetic toxicity defined as a result of disruption in gap junction intercellular communication has …
Epigenetic toxicity defined as a result of disruption in gap junction intercellular communication has …