Chemical activation of estrogen and aryl hydrocarbon receptor signaling pathways and their interaction in toxicology and metabolism
P Tarnow, T Tralau, A Luch - … on drug metabolism & toxicology, 2019 - Taylor & Francis
… signaling cascades and molecular crosstalk remain sparsely understood. Amongst other
reasons, this is often caused by a toxicological focus … and toxicological roles of both signaling …
reasons, this is often caused by a toxicological focus … and toxicological roles of both signaling …
Epigenetic changes and nontargeted radiation effects—is there a link?
O Kovalchuk, JE Baulch - Environmental and molecular …, 2008 - Wiley Online Library
… may be due to the epigenetic inheritance of instability signals through sperm. DNA
methylation is proposed to be a plausible candidate for an epigenetic signal that leads to transge…
methylation is proposed to be a plausible candidate for an epigenetic signal that leads to transge…
Nicotine-induced oxidative stress contributes to EMT and stemness during neoplastic transformation through epigenetic modifications in human kidney epithelial cells
… Nicotine is a component of cigarette smoke and mounting evidence suggests toxicity and …
, redox status, and growth signaling pathways were also evaluated to understand the …
, redox status, and growth signaling pathways were also evaluated to understand the …
Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis
… with various epigenetic mechanisms, which … epigenetic events such as DNA methylation
and histone acetylation, the major mechanisms include changes in the concentrations of signal …
and histone acetylation, the major mechanisms include changes in the concentrations of signal …
[HTML][HTML] Nanomedicine and epigenome. Possible health risks
B Smolkova, M Dusinska, A Gabelova - Food and Chemical Toxicology, 2017 - Elsevier
… of epigenetic … of epigenetic toxicity endpoints in the standard battery of NM safety assessment.
This article provides a comprehensive review of current knowledge on epigenetic toxicity …
This article provides a comprehensive review of current knowledge on epigenetic toxicity …
Intracellular Generation of Superoxide by TiO2 Nanoparticles Decreases Histone Deacetylase 9 (HDAC9), an Epigenetic Modifier
DT Jayaram, CK Payne - Bioconjugate Chemistry, 2020 - ACS Publications
… Overall, we find that TiO 2 NPs generate superoxide and this intracellular source of … not
result in intracellular ROS, suggesting the NPs are the source of the intracellular signal. …
result in intracellular ROS, suggesting the NPs are the source of the intracellular signal. …
Inhibition of gap junctional intercellular communication by toxic metals
M Vinken, L Ceelen, T Vanhaecke… - … research in toxicology, 2010 - ACS Publications
… contribute to their toxicity, modified cellular signaling seems to … junctional intercellular
communication in the toxicity triggered … that directly interfere with epigenetic processes. However, …
communication in the toxicity triggered … that directly interfere with epigenetic processes. However, …
Exposure to coplanar PCBs induces endothelial cell inflammation through epigenetic regulation of NF-κB subunit p65
D Liu, JT Perkins, MC Petriello, B Hennig - Toxicology and applied …, 2015 - Elsevier
… The aim of the current study is to investigate the epigenetic mechanisms that link PCBs and
… representing the ChIP signal as the fold increase in signal relative to the background signal. …
… representing the ChIP signal as the fold increase in signal relative to the background signal. …
Chromatin modifiers: A new class of pollutants with potential epigenetic effects revealed by in vitro assays and transcriptomic analyses
… were dysregulated, such as the estrogen signaling pathway, mTOR signaling pathway,
phosphatidylinositol signaling pathway, and PI3K-Akt signaling pathway. Estrogen is a crucial …
phosphatidylinositol signaling pathway, and PI3K-Akt signaling pathway. Estrogen is a crucial …
[HTML][HTML] Novel aspects of toxicity mechanisms of dioxins and related compounds
R Pohjanvirta, M Viluksela - International Journal of Molecular Sciences, 2020 - mdpi.com
… toxicity of dioxins and related compounds as well as selective modulators of AHR and both
its canonical and alternative signaling … of dioxins to cause epigenetic alterations. Two reviews …
its canonical and alternative signaling … of dioxins to cause epigenetic alterations. Two reviews …