The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
… The Ras-ERK and PI3K-AKT pathways can negatively regulate each other's activity. Such
cross-inhibition is often revealed when one pathway is chemically blocked, thereby releasing …
cross-inhibition is often revealed when one pathway is chemically blocked, thereby releasing …
The role of PI3K/Akt and ERK in neurodegenerative disorders
… on involvement of Akt/Erk cascade in the neurodegeneration. Akt has been reported to …
The following figure explains regarding Akt/Erk pathways in the area of neurodegenerative …
The following figure explains regarding Akt/Erk pathways in the area of neurodegenerative …
[PDF][PDF] The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma
F Meier, B Schittek, S Busch, C Garbe, K Smalley… - Front …, 2005 - article.imrpress.com
… -ERK (MAPK) and the PI3K-AKT (AKT) signaling pathways are … integrin are regulated by
these pathways and/or activate the … the MAPK and the AKT signaling pathways may represent …
these pathways and/or activate the … the MAPK and the AKT signaling pathways may represent …
Crosstalk between MAPK/ERK and PI3K/AKT signal pathways during brain ischemia/reperfusion
J Zhou, T Du, B Li, Y Rong, A Verkhratsky… - ASN neuro, 2015 - journals.sagepub.com
… (PI3K)/protein kinase B (AKT) and Raf/mitogen-activated protein kinase (MAPK)/extracellular
signal-regulated kinase (ERK 1/2 ) signaling pathways. … , PI3K/AKT, and Raf/MAPK/ERK 1/2 …
signal-regulated kinase (ERK 1/2 ) signaling pathways. … , PI3K/AKT, and Raf/MAPK/ERK 1/2 …
Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
Q Li, Z Li, T Luo, H Shi - Molecular biomedicine, 2022 - Springer
… pathways in tumorigenesis. In the current review, we describe the critical role of the PI3K/AKT/mTOR
and RAF/MEK/ERK signaling pathways … targeting the pathway in monotherapy and …
and RAF/MEK/ERK signaling pathways … targeting the pathway in monotherapy and …
The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches
A De Luca, MR Maiello, A D'Alessio… - Expert opinion on …, 2012 - Taylor & Francis
… (ERK) (MAPK) and the PI3K/AKT/mammalian target of rapamycin (mTOR) (PI3K) pathways
… Areas covered: In this review the key components of the MAPK and AKT pathways and their …
… Areas covered: In this review the key components of the MAPK and AKT pathways and their …
Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic …
JG Shelton, LS Steelman, JT Lee, SL Knapp… - Oncogene, 2003 - nature.com
… These pathways are interwoven as Akt can phosphorylate Raf and result in its inactivation, …
of Akt. In this study, the effects of activated Raf (Raf-1, A-Raf and B-Raf) and PI3K/Akt proteins …
of Akt. In this study, the effects of activated Raf (Raf-1, A-Raf and B-Raf) and PI3K/Akt proteins …
[PDF][PDF] A minireview: the role of MAPK/ERK and PI3K/Akt pathways in thyroid follicular cell-derived neoplasm
E Brzezianska… - Front Biosci (Landmark …, 2011 - article.imrpress.com
… Genetic and epigenetic alternations, concerning MAPK/ERK and PI3K/Akt signaling
pathways, contribute to their activation and interaction in consequence of malignant follicular cell …
pathways, contribute to their activation and interaction in consequence of malignant follicular cell …
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance
JA McCubrey, LS Steelman, SL Abrams, JT Lee… - Advances in enzyme …, 2006 - Elsevier
… The Raf/MEK/ERK pathway also influences … /MEK/ERK and PI3K/Akt pathways are important
pathways to target for therapeutic intervention. Inhibitors of Ras, Raf, MEK, PI3K, PDK, Akt, …
pathways to target for therapeutic intervention. Inhibitors of Ras, Raf, MEK, PI3K, PDK, Akt, …
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways
Y Hu, X Chen, TT Pan, KL Neo, SW Lee… - … -European Journal of …, 2008 - Springer
… /ERK1/2 and PI3K/Akt pathways … PI3K/Akt pathway functions in the cytoprotective effect of
SP in myocardial ischemia. To evaluate Akt activity after myocardial ischemia, we assessed Akt …
SP in myocardial ischemia. To evaluate Akt activity after myocardial ischemia, we assessed Akt …
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