TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non–small-cell lung cancer
RS Herbst, D Prager, R Hermann… - Journal of clinical …, 2005 - ascopubs.org
… On the basis of phase II results and the therapeutic advantage demonstrated … with erlotinib
with platinum-based and taxane chemotherapy, a phase III trial was conducted using erlotinib …
with platinum-based and taxane chemotherapy, a phase III trial was conducted using erlotinib …
Erlotinib (Tarceva): an update on the clinical trial program
RS Herbst - Seminars in oncology, 2003 - Elsevier
… - or third-line treatment for refractory ovarian cancer (doxorubicin and topotecan).28, 29 A
phase II clinical trial is in progress examining erlotinib in combination with carboplatin, and two …
phase II clinical trial is in progress examining erlotinib in combination with carboplatin, and two …
Erlotinib Hydrochloride
LA Sorbera, J Castaner, JS Silvestre… - Drugs of the Future, 2002 - access.portico.org
… Erlotinib (150 mg/day po until disease progression) was shown to have significant
antitumor activity in a phase II trial involving 56 patients suffering from stage IIIB/IV or recurrent …
antitumor activity in a phase II trial involving 56 patients suffering from stage IIIB/IV or recurrent …
Erlotinib hydrochloride.
J Dowell, JD Minna, P Kirkpatrick - Nature Reviews Drug Discovery, 2005 - nature.com
… , respectively, conducted a Phase II trial of erlotinib and bevacizumab in advanced … The
combination was safe and well-tolerated, and enough activity was seen to justify a Phase III …
combination was safe and well-tolerated, and enough activity was seen to justify a Phase III …
Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma
MD Prados, KR Lamborn, S Chang, E Burton… - Neuro …, 2006 - academic.oup.com
… Recent data from a phase 3 trial of erlotinib in combination with gemcitabine in patients with
advanced pancreatic cancer showed a 23.5% improvement in survival with the addition of …
advanced pancreatic cancer showed a 23.5% improvement in survival with the addition of …
Erlotinib HCL for glioblastoma multiforme in first relapse, a phase II trial
A Yung, J Vredenburgh, T Cloughesy… - Journal of Clinical …, 2004 - ascopubs.org
… Methods: A multi-institutional phase II clinical trial of the … Pharmacokinetic measurements
are being obtained in this study. … Conclusions: These preliminary data suggest that erlotinib is …
are being obtained in this study. … Conclusions: These preliminary data suggest that erlotinib is …
… safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: results from a phase II …
AN Gordon, N Finkler, RP Edwards… - International Journal of …, 2005 - ijgc.bmj.com
… toxicities, and ease of administration, erlotinib is a possible candidate for … a phase II study
of erlotinib in 34 heavily pretreated patients with relapsed cancer of the ovary at the phase I …
of erlotinib in 34 heavily pretreated patients with relapsed cancer of the ovary at the phase I …
TRIBUTE-A phase III trial of erlotinib HCl (OSI-774) combined with carboplatin and paclitaxel (CP) chemotherapy in advanced non-small cell lung cancer (NSCLC)
RS Herbst, D Prager, R Hermann, V Miller… - Journal of Clinical …, 2004 - ascopubs.org
… TRIBUTE was a prospective, placebo-controlled study randomizing patients (pts) with
previously untreated advanced (Stage IIIB / IV) NSCLC to receive erlotinib at 150 mg/d or placebo (…
previously untreated advanced (Stage IIIB / IV) NSCLC to receive erlotinib at 150 mg/d or placebo (…
Phase II clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non–small-cell lung cancer
R Pérez-Soler - Clinical lung cancer, 2004 - Elsevier
… The results of 3 phase II studies with erlotinib in non–small-cell lung cancer (NSCLC) are …
Rash severity is predictive of increased survival with erlotinib HCl. Proc Am Soc Clin Oncol …
Rash severity is predictive of increased survival with erlotinib HCl. Proc Am Soc Clin Oncol …
Pharmacokinetics and pharmacodynamics: maximizing the clinical potential of Erlotinib (Tarceva)
M Hidalgo, D Bloedow - Seminars in oncology, 2003 - Elsevier
… a phase II trial with erlotinib in patients with non-small cell lung cancer, 17 findings from
recent phase II studies … NSCLC treated with Tarceva (erlotinib HCl; OSI-774). Final report of a …
recent phase II studies … NSCLC treated with Tarceva (erlotinib HCl; OSI-774). Final report of a …
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