… DNA methylation, particularly in eukaryotic systems. In 1975, several groups of researchers
… a role for DNA methylation in the regulation of gene expression in eukaryotes (Riggs, 1975; …

… Understanding the factors that determine genomic methylation patterns represents a major
… that DNA methylation may have many roles in vivo, including the control of gene expression, …

… the large-genome cell manage to correctly control its own genes, which … I suggest that DNA
methylation of the vertebrate type has … effects of genome expansion in complex eukaryotes by …

… DNA METHYLATION AND DEVELOPMENT Although it is quite clear from experiments in
tissue culture that DNA methylation inhibits gene expression, it is not obvious how this …

… inside the genes (14). Furthermore, we still do not understand the mechanism by which DNA
methylation impacts gene … of heavier methylation of modestly transcribed genes than those …

… It is the very variable levels of base modifications which have made the study of DNA
methylation so frustrating and have led to the conclusion that several different functions may be …

… of de novo patterns of DNA methylatton is characterized … of DNA methylation by an essentially
unknown mechanism. In this review, some of the general concepts of DNA methylation in …

… in the ovalbumin gene region remain unmethylated, even in sperm DNA, and … DNA
methylation of the ovalbumin gene locus in chromatin of chicken oviduct show that when the gene …

… two global mechanisms of gene regulation, DNA methylation and histone deacetylation, can
be linked by MeCP-2.61,62 However, in some instances DNA methylation has been shown …

… with DNA methylation at specific sites (185). In the elucidation of the function that DNA methylation
has in gene regulation in higher eukaryotes… The virion DNA that is encapsidated in the …