… Benefits of probiotic treatment prior to experimental sepsis included reduced mortality as
well as a decrease in inflammatory cytokines IL-2 and IL-22 when compared to saline treated …

… mortality rate of severe sepsis suggests that the need for additional therapies is high. Clinical
… potential therapeutic targets that may be exploited in the future treatment of severe sepsis. …

… that targets the underlying mechanism of sepsis. During the last decades therapies developed
… development strategies for the treatment of sepsis and septic shock need to be revisited [ …

… experimental basic studies have been undergone to identify the effective therapy for sepsis
and these novel therapies … shed light on novel therapeutic targets for the treatment of sepsis. …

… therapies failed in human trials. In addition, this article examines potential future sepsis targets
and … The mice included in these experiments are often 8 to 12 weeks old and they are not …

… of experimental sepsis, and discuss the therapeutic potential of several HMGB1-targeting …
Although HMGB1 appears to be a feasible therapeutic target for experimental sepsis (Refs …

… as well as deliver therapeutic agents to targeted tissues and … new experimental and clinical
approaches for therapeutic … The ER-β is an important therapeutic target because it is not …

… dysregulated immune response during sepsis and plays a very … during sepsis to design
future target-based therapeutics … sepsis and its targeting as a future therapeutic approach. …

… in patients who are septic. These … sepsis is supported by the fact that acute tubular necrosis
(ATN) is an uncommon finding in histopathologic studies of human and experimental septic …

… in an experimental model of gram-negative peritoneal sepsis and … recently as an interesting
potential therapeutic target (15). … anti-toxin therapy. This is certainly true in the case of …