… of the genetic landscape that underpins Wilms tumour. We begin with the epidemiology,
focusing on the narrow developmental window of Wilms tumour and the genetic risk factors that …

… renal tumours: ~90% being Wilms tumours (WTs) and ~10% other primary renal tumours. In
… hyperplastic nephrogenic rests, with typical genetic changes. Nephrogenic rests are found in …

… 11 are needed for Wilms’ tumour to develop. Gross genetic changes affecting this part of …
(‘A’ in this figure) that lies close to the tumour suppressor gene. The first hit is usually a point …

… crucial gene alterations, this has not been the case. Mutations in Wilms tumour 1 (WT1), Wilms
tumour gene … In summary, the known genetic alterations that occur in Wilms' tumours are …

… often associated with bilateral Wilms’ tumour than is aniridia,12 suggesting a tighter linkage
between these genes than that between the aniridia and Wilms’ tumour genes. The fourth …

… of genetic changes in chromosome 11 in Wilms' tumours. Using a range of probes for regions
11p15, 11p13 and llq we have screened DNA from 14 Wilms' tumours … Wilms' tumours. In …

… in Wilms” tumour, we would expect mutations affecting this gene to be present in a significant
number of tumours, … We analysed 13 tumours by northern blot (Fig. 3) and found that each …

… genetic aetiology of Wilms' tumour… genes in Wilms' tumours, such as RASSF1A,
p16INK4A/CDKN2A, DAPK and MGMT, although less of an association has been found with these …

… tion genes, a role for other genes in the development of WTs is implied by the somatic
occurrence of genetic … Determining the pattern of presence or absence of these various genetic …

… genetics are turning out to be much more complex. Evidence is accumulating that several
different genetic loci may play a role in Wilms' tumour … isolated predisposition gene (WT1) are …