… The haploid human genome contains … DNA methylome. The methylation status of cytosines
in CpGs and occasionally in non-CpG cytosines influences protein–DNA interactions, gene …

… , no single method can profile the methylome in great detail. A combination of several
methodologies is needed to comprehensively interrogate DNA methylation by microarray. The …

… of DNA molecules is a key mechanism associated with human disease, altered gene … Using
reduced representation bisulphite sequencing (RRBS) technology we have analysed DNA …

… resource of vertebrate and invertebrate DNA methylomes, it showcases the power of
reference-free epigenome analysis in species for which no reference genomes are available, and it …

… the dynamic aspect of the methylome normally masked in steady-state measurements. …
Having quantified passive demethylation at the genome scale, we sought to determine the …

… with high gene body methylation in highly expressed genes. Using the second method,
MSCC, we gathered genome-scale data for 1.4 million HpaII sites and confirmed that gene body …

… small genome coverage. To evaluate the diversity of methylation in CRC at the genome-scale
level, we used a new version of the lllumina HumanMethylation450 array to analyze DNA …

… We find evidence for genome-scale oscillatory dynamics of DNA methylation during this
transition… can be created by molecular processes, not only locally but also on the genome scale. …

… of low promoter methylation and high gene-body methylation in highly expressed …
genome-scale data for ∼1.4 million HpaII sites in the DNA of B-lymphocytes and confirmed that gene…

… methylomes). Such comparative studies rely both on the ability to obtain genome-scale …
Methods used to annotate them on a genomic scale have been based only on sequence …