… of DNA methylation on human y-globin gene expression, using a novel in vitro DNA methylation
… To study the effect of DNA methylation on globin gene expression we have modified this …

… Our results on the role of DNA methylation at this locus strongly suggest that whatever the
molecular mechanism at the source of this disease, activation of the γ-globin genes should …

… 5' and 3' ends of the 13-globin gene but not in the 90-base-… of DNA methylation in the
regulation of the f3-globin gene, 50… -human hybrid gene, and these inserts were methylated by …

… partial methylation, however, donot-conform to the model-that transcribed genes are … We
also find a well-defined 3.5-kilobase region of DNA 5' to the a-globin gene cluster in which all …

… globin genes are a suitable system for studying the correlation of gene expression with
DNA methylation. Genes expressed in the fetal (Gy, Ay) and adult (6, p) phases of human …

… DNA-mediated gene transfer can also be used to evaluate the effect ofmethylation on gene
expression. When the tissue-specific human y- or 3-globin genes were methylated in vitro …

… changes in globin locus DNA methylation with globin gene switching… between gene expression
and globin promoter methylation in … the role of DNA methylation in globin gene switching. …

… role for methylation in silencing rho-globin gene transcription in … of embryonic globin genes
during normal erythropoiesis. … mechanisms of gene regulation, DNA methylation and histone …

… by cells in using methylation as a regulatory modality. In this … role of DNA methylation in
vertebrate gene regulation during … of DNA methylation in silencing of the human ɛ‐globin gene …

… between DNA methylation and 7-globin gene expression during ontogeny. -y-Globin gene
methylation is … The methylation status of the 7-globin genes may be as sessed using the …