N-linked Glycosylation Profiling of Pancreatic Cancer Serum Using Capillary Liquid Phase Separation Coupled with Mass Spectrometric Analysis

J Zhao, W Qiu, DM Simeone… - Journal of proteome …, 2007 - ACS Publications
… human serum. We demonstrate the presence of specific glycans in pancreatic cancer serum
… N-linked glycopeptides from normal and pancreatic cancer serum were enriched using two …

Evidence of altered glycosylation of serum proteins prior to pancreatic cancer diagnosis

S Krishnan, HJ Whitwell, J Cuenco… - International journal of …, 2017 - mdpi.com
… of altered glycosylation of several serum proteins prior to pancreatic cancer diagnosis, …
In summary, we have profiled numerous serum protein glycosylation sites and compared …

Serum N‐Glycome analysis reveals pancreatic cancer disease signatures

GCM Vreeker, RG Hanna‐Sawires… - Cancer …, 2020 - Wiley Online Library
glycosylation related to pancreatic cancer. A few studies on N-glycosylation profiles in
pancreatic cancer have … Here, we use an automated protocol for the analysis of the total serum N-…

Glycosylation changes in serum proteins identify patients with pancreatic cancer

A Drabik, A Bodzon-Kulakowska, P Suder… - Journal of proteome …, 2017 - ACS Publications
… (11, 12) Therefore, in the present study, we investigated the serum N-glycome profiles of
patients with pancreatic cancer and nonmalignant controls to identify potential new biomarkers. …

[HTML][HTML] The glycosylation landscape of pancreatic cancer

J Munkley - Oncology Letters, 2019 - … .spandidos-publications.com
… Increased fucosylation can be detected in serum from patients with pancreatic cancer (56), …
To fully exploit glycans clinically it will be vital to fully profile the pancreatic cancer glycome …

High-density and targeted glycoproteomic profiling of serum proteins in pancreatic cancer and intraductal papillary mucinous neoplasm

L Aronsson, R Andersson, M Bauden… - Scandinavian journal …, 2018 - Taylor & Francis
… Furthermore, the analytical method used in the present study measured the glycosylation
levels of serum proteins and no additional characterization of the individual glycans was …

Large-scale identification of core-fucosylated glycopeptide sites in pancreatic cancer serum using mass spectrometry

Z Tan, H Yin, S Nie, Z Lin, J Zhu, MT Ruffin… - Journal of proteome …, 2015 - ACS Publications
Analysis on 13 sample sets was performed in this study, … from pancreatic cancer serum
(Figure 3B) is also similar to that of N-glycosylation sites in proteins derived from human pancreas

A multiplexed bead assay for profiling glycosylation patterns on serum protein biomarkers of pancreatic cancer

C Li, E Zolotarevsky, I Thompson, MA Anderson… - …, 2011 - Wiley Online Library
… Their glycosylation levels were found to be elevated in pancreatic cancer serum in this study
using a RP HPLC-fraction microarray method 28. Both of these two glycoproteins produced …

Comparison of sialylated N‐glycopeptide levels in serum of pancreatic cancer patients, acute pancreatitis patients, and healthy controls

H Kontro, S Joenväärä, C Haglund, R Renkonen - Proteomics, 2014 - Wiley Online Library
… one or two, but not all, N-glycosylation sites in a specific glycoprotein. In conclusion, the
analysis shows that pancreatic cancer, and acute pancreatitis are associated with changes in …

Isomer-specific profiling of N-glycans derived from human serum for potential biomarker discovery in pancreatic cancer

Y Liu, C Wang, R Wang, Y Wu, L Zhang, BF Liu… - Journal of …, 2018 - Elsevier
tumor markers are glycoproteins with altered glycan profiles [6,7]. Alterations in glycosylation
are frequently observed in serum … used as serum biomarkers for diagnosis of cancers [8,9]. …