… tyrosine kinase inhibitor‐sensitizing and resistance mutations in the plasma DNA of patients with advanced non–small cell lung cancer during treatment with erlotinib

BS Sorensen, L Wu, W Wei, J Tsai, B Weber, E Nexo… - Cancer, 2014 - Wiley Online Library
… -sensitizing EGFR mutations were taken immediately before treatment with erlotinib.
Additional blood samples were taken at timed intervals until erlotinib treatment was withdrawn. …

Erlotinib (Tarceva®): a promising drug targeting epidermal growth factor receptor tyrosine kinase

AM Bulgaru, S Mani, S Goel… - Expert review of …, 2003 - Taylor & Francis
… Large inter- and intrapatient pharmacokinetic variability was observed with oral erlotinib
treatment, although relatively dose-proportional increases are observed when doses are …

Erlotinib for frontline treatment of advanced non–small cell lung cancer: a phase II study

G Giaccone, M Gallegos Ruiz, T Le Chevalier… - Clinical Cancer …, 2006 - AACR
growth factor receptor tyrosine kinase mutation. Two progressing patients exhibited epidermal
growth factor … Conclusions: Erlotinib shows significant antitumor activity in the first-line …

Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study

F Cappuzzo, T Ciuleanu, L Stelmakh, S Cicenas… - The lancet …, 2010 - thelancet.com
… The oral epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitor erlotinib has …
; BO18192) study to assess use of erlotinib as maintenance therapy in patients with non-…

The role of erlotinib (Tarceva, OSI 774) in the treatment of non-small cell lung cancer

R Perez-Soler - Clinical cancer research, 2004 - AACR
Erlotinib (Tarceva) is a specific epidermal growth factor … Gefitinib (Iressa) shares with erlotinib
both a common chemical … 2-fold less potent than erlotinib. Clinical studies have resulted in …

… I/II Study of HSP90 Inhibitor AUY922 and Erlotinib for EGFR-Mutant Lung Cancer With Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase …

ML Johnson, HA Yu, EM Hart, BB Weitner… - Journal of Clinical …, 2015 - ascopubs.org
growth factor receptor. We conducted a phase I/II trial to evaluate AUY922 and erlotinib
patients with EGFR-mutant lung cancer and disease progression during erlotinib treatment. …

Erlotinib in the treatment of advanced non-small cell lung cancer: an update for clinicians

Y Wang, G Schmid-Bindert… - Therapeutic advances in …, 2012 - journals.sagepub.com
… epidermal growth factor receptor (EGFR) has become an important target in the treatment
of … inhibitors, with a focus on erlotinib, as first-line treatment towards a form of personalized …

… lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemotherapy (EURTAC) …

R Rosell, R Gervais, A Vergnenegre… - Journal of clinical …, 2011 - ascopubs.org
erlotinib compares with CT in EGFR-mutant Caucasian p. We have performed a prospective,
randomized phase III study comparing erlotinibErlotinib as first-line treatment for advanced …

Erlotinib (Tarceva): an update on the clinical trial program

RS Herbst - Seminars in oncology, 2003 - Elsevier
… with the intracellular catalytic domain of epidermal growth factor receptor (HER1/EGFR)
tyrosine … Erlotinib treatment was generally well tolerated and the most commonly reported side …

Erlotinib

M Steins, M Thomas, M Geißler - Small molecules in oncology, 2018 - Springer
erlotinib. Extracellular binding of ligands like the epidermal growth factor (EGF) and transforming
growth factor-… survival, 31% of patients treated with erlotinib in this study were alive at 1 …