… Growth factor receptors comprise one such class of targets, and therapies directed … growth
factor receptor family, which includes a group of related proteins that regulate tumor cell growth…

… Such oncogenic homologs provide invaluable clues to the mechanisms of normal growth
factor receptors, in addition to enhancing our understanding of cellular transformation and …

… transforming growth factor-α (TGF-α) bound to the EGFR can already dissociate from the
receptor … to EGFR recycling as compared to the lysosomal degradation of EGF-bound receptors. …

… function of the epidermal growth factor (EGF) receptor (EGFR), … growth factor receptor (EGFR)
regulates the intracellular effects of ligands such as EGF and transforming growth factor-α (…

… growth factor receptor (EGFR) is a transmembrane receptor … related receptors: the epidermal
growth factor receptor itself (… 2, 3, 4 These receptors trigger downstream signaling pathways …

… growth factor receptor (EGFR) antibodies (37). Inhibition of IGF signaling, however, seems
capable of blocking the growth … than single receptor blockade at inhibiting the growth of EGFR-…

… of the fibroblast growth factor (FGF) family of growth factors mediate their … receptor tyrosine
kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4. Unlike other growth factors, …

… Furthermore, it was this growth factor receptor that first identified a relationship between
an … Gullick WJ 2001 The type 1 growth factor receptors and their ligands considered as a …

… of several of the growth factor receptors can be identified. For example the receptors for
insulin", macrophage colony-stimulating factor (CSF-1)", and epidermal growth factor" have, in …

… Growth factors are soluble effector molecules of cellular … Growth factor receptors therefore
play a key role in transmitting … growth factor receptor (EGFR) was one of the earliest growth …