Antitumor activity of a new N-substituted thiourea derivative, an EGFR signaling-targeted inhibitor against a panel of human lung cancer cell lines
X Xiong, H Liu, L Fu, L Li, J Li, X Luo, C Mei - Chemotherapy, 2008 - karger.com
… low-molecularweight quinazoline derivatives with different … -3-ylmethyl)-thiourea, and
the inhibitory activity of DC27 tested … and proved that it inhibited epidermal growth factor (EGF)-…
the inhibitory activity of DC27 tested … and proved that it inhibited epidermal growth factor (EGF)-…
Synthesis and evaluation of new thiourea derivatives as antitumor and antiangiogenic agents
W Bai, J Ji, Q Huang, W Wei - Tetrahedron Letters, 2020 - Elsevier
… growth factor receptors (VEGFR), platelet-derived growth factor receptor (PDGFR) and fibroblast
growth factor … series (4, 5, 10) of thiourea derivatives. All synthesized compounds were …
growth factor … series (4, 5, 10) of thiourea derivatives. All synthesized compounds were …
In Silico Study of Thiourea Derivatives as Potential Epidermal Growth Factor Receptor Inhibitors
N Roslan, KBA Halim, NM Bunnori… - Journal of …, 2023 - World Scientific
… selectivity of epidermal growth factor receptor tyrosine kinase (… The potential of theoretically
designed thiourea derivatives … New hybrid molecules of the thiourea derivative moiety were …
designed thiourea derivatives … New hybrid molecules of the thiourea derivative moiety were …
Design, synthesis and antitumor evaluation of a new series of N‐substituted‐thiourea derivatives1
… Epidermal growth factor receptor (EGFR) is one of the important PTK. EGFR and its
ligands (EGF and TGF-α) have been found to have high expression levels in many tumors of …
ligands (EGF and TGF-α) have been found to have high expression levels in many tumors of …
Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study
SY Abbas, RAK Al-Harbi, MAMS El-Sharief - European Journal of …, 2020 - Elsevier
… Beside to the various biological properties of thiourea derivatives, they are among the most
… Some of N-substituted-thiourea derivatives have been reported as epidermal growth factor …
… Some of N-substituted-thiourea derivatives have been reported as epidermal growth factor …
Biphenylurea/thiourea derivatives tagged with heteroarylsulfonamide motifs as novel VEGFR2 inhibitors; Design, synthesis and anti-angiogenic activity
… growth factor receptor 2 (VEGFR2) has emerged as a vital tool for cancer treatment. In this
study, a new series of biphenylurea/thiourea derivatives … of these derivatives against four …
study, a new series of biphenylurea/thiourea derivatives … of these derivatives against four …
Design, synthesis, and evaluation of new benzimidazole thiourea derivatives as antitumor agents
MH Aboutaleb, NS El‐Gohary… - Archiv der …, 2023 - Wiley Online Library
… Novel benzimidazole thiourea derivatives were designed and synthesized based on … endothelial
growth factor receptor-2 (VEGFR-2), B-Raf (V600E) , and platelet-derived growth factor …
growth factor receptor-2 (VEGFR-2), B-Raf (V600E) , and platelet-derived growth factor …
Design, synthesis and biological evaluation of some new 1, 3, 4-thiadiazine-thiourea derivatives as potential antitumor agents against non-small cell lung cancer cells
FAF Ragab, SA Abdel-Aziz, M Kamel, AMA Ouf… - Bioorganic …, 2019 - Elsevier
… New 1,3,4-thiadiazine-thiourea derivatives have been synthesized. All the synthesized …
to play roles in NSCLC specifically: vascular endothelial growth factor receptor 2 (VEGFR2), B-…
to play roles in NSCLC specifically: vascular endothelial growth factor receptor 2 (VEGFR2), B-…
Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents
PC Lv, HQ Li, J Sun, Y Zhou, HL Zhu - Bioorganic & medicinal chemistry, 2010 - Elsevier
… Among the growth factor receptor kinases that have been identified as being important in
cancer is epidermal growth factor receptor (EGFR) kinase. Activation of EGFR may be because …
cancer is epidermal growth factor receptor (EGFR) kinase. Activation of EGFR may be because …
Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti …
WAA Fadaly, MTM Nemr, NM Kahk - Bioorganic Chemistry, 2024 - Elsevier
… Furthermore, it involves local release of vascular growth factors, … Several growth factors
have been shown to promote … endothelial growth factor (VEGF), a cell regulatory factor affects …
have been shown to promote … endothelial growth factor (VEGF), a cell regulatory factor affects …
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