… Schematic of potential endpoints for phase III pivotal chronic heart failure trials (A) or acute
heart failure trials (B). The hierarchy (or order ranking) of the endpoint options to measure …

… trials conducted in different world regions, from heart failure with preserved ejection fraction
(HF-PEF), heart failure … HF trials conducted in different world regions, from heart failure with …

… The Vasodilator-Heart Failure Trial (V-HeFT) data base provides information on the …
entered into two trials that evaluated the effect of vasodilator therapy on survival in heart failure. …

… Despite neutral results in many acute HF trials, recent studies including RELAX-AHF, …
recent trials in acute HF and outline strategies to improve the potential for success in future trials. …

… The purpose of this review was to evaluate temporal trends in representation of women
as authors in heart failure (HF) randomized controlled trials (RCTs) published in high-impact …

… For example, hypertension, a major cause of heart failure in … exist between black and white
patients with heart failure. … the first and second Vasodilator-Heart Failure Trials (V-HeFT I and …

… Therefore, we suggest that disease management programs for heart failure patients include
the elements found to be efficacious in these trials: multidisciplinary teams, an emphasis on …

… ) trials, which included a broad spectrum of heart failure … , heart failure trials are often now
designed with cause-specific composite endpoints (eg cardiovascular mortality or heart failure …

… Many trials use composite outcomes as primary or … of composite outcomes in heart failure
trials, give recommendations for … been defined and used in heart failure drug and device trials. …

… of patients with heart failure: a scientific statement from the American Heart Association.  …
represented in HF clinical trials. Underrepresentation in clinical trials limits the generalizability …