… histone modifications in cancer. The major emphasis will be on the clinical utility of histone
modifications, but I will also provide a brief account of how they may lead to cancer initiation. …

… -translational histone modifications are known to be altered in cancer cells, and loss of
selected histone acetylation and methylation marks has recently been shown to predict patient …

… Another important histone modification in gene expression is histone methylation. Histone
… arginines can be mono- or dimethylated, increasing the complexity of histone modifications. …

… and studied epigenetic histone modifications with a proven … and methylation / demethylation
of histone proteins, as well as the … between histone modifications and certain types of cancer …

… of cancer may have specific patterns of histone modifications (histone modification signatures),
a … Finally, since histone modifications are reversible, they represent potential targets for …

… histone modifications of the mechanisms responsible for the control and maintenance of the
histone … of aberrant histone modifications as prognostic factors in cancer will be reviewed. …

… novel post-translational modifications that have been observed … described the role of histone
modifications that can occur on … thus form the basis of novel strategies for cancer therapy. …

… histone modifications play important roles in carcinogenesis. It was reported that global histone
modification patterns are predictors of cancer … evaluate histone lysine (HxKy) and histone …

… histones and their modifications are present ubiquitously, our results in prostate cancer raised
the possibility that histone modification … cancer types. Furthermore, the prognostic utility of …

… of epigenetic modifications is central to many common human diseases, including cancer. …
the mosaic patterns of DNA methylation and histone modification in cancer cells on a gene-by-…