… In this article we review briefly the therapeutic development of IFNs, particularly IFN-β, as
an example of a successful cytokine therapeutic. We also review the development of anti-TNF …

… therapeutics has emerged. Novel synthetic strategies allow for the modulation of pharmacokinetic
properties and target … of molecular targets that reaches beyond historically-dominant …

… Numerous opportunities for novel therapeutics … target these receptors. A substantial proportion
of all worldwide prescription drug sales today are generally attributed to drugs that target …

The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood–…

… this protective role can inappropriately target self tissues and … of therapeutic intervention,
such as in cardiopulmonary bypass. Here we review the history of anti-complement therapeutics …

… This review will focus on these promising new developments, will discuss them in terms of
their potential for drug development and will further consider what new information on GAG …

… , and human therapeutic antibodies. … target tissue still remains to be addressed to avoid
unwanted side effects as a result of systemic treatment while achieving meaningful therapeutic …

… This article reviews the historical evolution of sepsis therapy (Table 1) and identifies possible
… In addition, this article examines potential future sepsis targets and considers which trial …

… In addition, peptide drug candidates are being generated against a range of molecular
targets that reach beyond historically-dominant extracellular hormone receptors. Peptides that …

… review, we first explain the involvement of several cytokines in many common diseases
involving cytokine overproduction, and identify key targets for … the idea that therapeutic targets for …