Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

N Coppieters, BV Dieriks, C Lill, RLM Faull… - Neurobiology of …, 2014 - Elsevier
… All the brains received in the brain bank are routinely stained for Aβ, tau, and ubiquitin and
… A total of 29 neurologically normal and 29 AD postmortem human brains were used for this …

[HTML][HTML] DNA methylation signatures within the human brain

C Ladd-Acosta, J Pevsner, S Sabunciyan… - … Journal of Human …, 2007 - cell.com
… normal DNA methylation might distinguish individual brain regions. We determined the
quantitative DNA methylation … shown to be implicated in human cancer. We initially analyzed 76 …

Distinct DNA methylation changes highly correlated with chronological age in the human brain

DG Hernandez, MA Nalls, JR Gibbs… - Human molecular …, 2011 - academic.oup.com
… distinct brain regions, and furthermore, that the DNA methylation … of age on DNA methylation
status in human brain. We find that … between CpG methylation and aging of the human brain. …

Evolution of DNA methylation in the human brain

H Jeong, I Mendizabal, S Berto, P Chatterjee… - Nature …, 2021 - nature.com
… the human brain. Here we have elucidated DNA methylation changes during recent human
brain … We demonstrate dynamic evolutionary trajectories of DNA methylation in cell-type and …

Comprehensive DNA methylation and hydroxymethylation analysis in the human brain and its implication in mental disorders

T Kato, K Iwamoto - Neuropharmacology, 2014 - Elsevier
… of the mouse and human brain (Lister et al., 2013). This study identified developmentally …
DNA methylation changes, and found that genome-wide reconfiguration of the DNA methylation

Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals

PR Braun, S Han, B Hing, Y Nagahama… - Translational …, 2019 - nature.com
… The use of surrogate tissues has become common in identifying methylation changes … as
surrogates for DNA methylation in the brain. Blood, saliva, buccal, and live brain tissue samples …

DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons

KD Siegmund, CM Connor, M Campan, TI Long… - PloS one, 2007 - journals.plos.org
… to confirm that the developmental DNA methylation changes as observed in this study are
a … of the human cerebral cortex. Furthermore, we monitored DNA methylation changes at a …

Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients

LF Wockner, EP Noble, BR Lawford… - Translational …, 2014 - nature.com
… In this study, we analysed DNA methylation status in brain tissue, the primary tissue of …
methylation array with very extensive coverage of the potential methylation sites in the human

DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

JV Sanchez-Mut, E Aso, N Panayotis, I Lott, M Dierssen… - Brain, 2013 - academic.oup.com
… To determine if these genes underwent DNA methylation changes in the disorder, we
hybridized the frontal cortex samples from two well-established models of Alzheimer’s disease in …

Aging effects on DNA methylation modules in human brain and blood tissue

S Horvath, Y Zhang, P Langfelder, RS Kahn… - Genome biology, 2012 - Springer
… and DNA methylation levels and in brain and blood tissue. Third, we analyze four novel WB
DNA methylation … network analysis (WGCNA) of multiple methylation data sets. We apply the …