… A novel animal model of high human renin hypertension in the rat attest to target organ …
therapy all lead to sharp increases in plasma renin activity, aliskiren offers a novel circumvention. …

… basic mechanisms of target organ damage induced by RAS in each organ and the effect of
… (ARBs), on target organ damage are discussed, together with the recent paradigm of RAS. …

… Binding of renin to this receptor increases the catalytic activity of renin by about four- to … I)
in solution, gains enzyme activity comparable to that of renin by binding to the (P)RR, that is, the …

… human renin infusion, indicating that the SFO is of pivotal importance for the central pressor
effect of Ang II. When in transgenic animals carrying human renin and human AOGEN, the …

… Our data show that minimal doses of aliskiren, a new human renin inhibitor, provided
target organ protection without significant effects on BP, as did the AT1-receptor blocker. The …

… In the case that skin is indeed a target organ for Ang II, it … angiotensinogen by the enzymes
renin (resulting in Ang I) and … of angiotensinogen, renin and ACE in diverse human cutaneous …

… the cardiovascular actions of the classical RAAS in target organs (35). … carrying human
renin and human angiotensinogen, water intake decreased (67). Thus, the subfornical organ is of …

… The renin-angiotensin system plays an important part in cardiovascular … II on target organs
such as the kidneys, the blood vessels, and the adrenals.' Standard teaching is that renin …

… drugs have been demonstrated to protect against target organ damage, reversing or preventing
its … target organ damage. THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) …

… to human mesangial cells where prorenin and renin activated ERK 1… [14] observed that
recombinant human renin stimulated … , and PAI-1 in rat and human mesangial cells. Collagen and …