Chimeric antigen receptor (CAR) Treg: a promising approach to inducing immunological tolerance
Q Zhang, W Lu, CL Liang, Y Chen, H Liu… - … in immunology, 2018 - frontiersin.org
… efficiently engineered with a predetermined antigen-specificity via transfection of viral vectors
encoding specific T cell receptors (TCRs) or chimeric antigen receptors (CARs). Compared …
encoding specific T cell receptors (TCRs) or chimeric antigen receptors (CARs). Compared …
[HTML][HTML] T cells expressing chimeric antigen receptor promote immune tolerance
A Pierini, BP Iliopoulou, H Peiris, M Pérez-Cruz… - JCI insight, 2017 - ncbi.nlm.nih.gov
… Here, we use a modular system based on a chimeric antigen receptor (CAR) that binds …
Thus, transient genetic modification to produce mAbCAR T cells led to durable immune …
Thus, transient genetic modification to produce mAbCAR T cells led to durable immune …
Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance
… antigens, data from preclinical models show that donor-reactive Tregs are more effective than
polyclonal Tregs in promoting transplant tolerance … receptors or chimeric antigen receptors …
polyclonal Tregs in promoting transplant tolerance … receptors or chimeric antigen receptors …
An introduction to chimeric antigen receptor (CAR) T‐cell immunotherapy for human cancer
S Feins, W Kong, EF Williams… - American journal of …, 2019 - Wiley Online Library
… In this review, we introduce the concept of using CAR T cells to break immunological tolerance
to tumors, highlight several challenges in the field, discuss the utility of biomarkers in the …
to tumors, highlight several challenges in the field, discuss the utility of biomarkers in the …
Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges
EQ Han, X Li, C Wang, T Li, S Han - Journal of hematology & oncology, 2013 - Springer
… trials regarding cancer immunotherapy with chimeric antigen receptor (CAR)-engineered T
… patients to better tackle the issue of immunological tolerance. Adoptive immunotherapy (AIT) …
… patients to better tackle the issue of immunological tolerance. Adoptive immunotherapy (AIT) …
Do treg speed up with CARs? Chimeric antigen receptor treg engineered to induce transplant tolerance
M Kaljanac, H Abken - Transplantation, 2023 - journals.lww.com
… With that, CAR Treg are providing hope in establishing allospecific, localized immune
tolerance in the long term‚ and the first clinical trials administering CAR Treg for the treatment of …
tolerance in the long term‚ and the first clinical trials administering CAR Treg for the treatment of …
Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia
H Dai, W Zhang, X Li, Q Han, Y Guo, Y Zhang… - …, 2015 - Taylor & Francis
The engineering of T lymphocytes to express chimeric antigen receptors (CARs) aims to
establish T cell-mediated tumor immunity rapidly. In this study, we conducted a pilot clinical trial …
establish T cell-mediated tumor immunity rapidly. In this study, we conducted a pilot clinical trial …
Strategies to address chimeric antigen receptor tonic signaling
A Ajina, J Maher - Molecular cancer therapeutics, 2018 - AACR
… Finally, through the prism of endogenous T-cell tonic signaling and its important regulatory
role in immune tolerance and cell-mediated adaptive immunity, we posit a number of …
role in immune tolerance and cell-mediated adaptive immunity, we posit a number of …
Chimeric antigen receptor T-cell therapy for the community oncologist
… An advantage of cell-based immunotherapy is the ability to overcome immune tolerance and
generate immune memory. Advances in gene transfer technologies have led to the strategy …
generate immune memory. Advances in gene transfer technologies have led to the strategy …
Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions
KJ Curran, HJ Pegram… - The journal of gene …, 2012 - Wiley Online Library
… through the introduction of a chimeric antigen receptor (CAR) allows for generation of
tumor‐targeted T cells. Once expressed by T cells, CARs combine antigen‐specificity with T cell …
tumor‐targeted T cells. Once expressed by T cells, CARs combine antigen‐specificity with T cell …
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