Protein complexes, big data, machine learning and integrative proteomics: lessons learned over a decade of systematic analysis of protein interaction networks
… the PPI networks generated in these studies were based primarily on proteomic data only, …
information, such as gene co-expression data, genetic associations, and other evidence …
information, such as gene co-expression data, genetic associations, and other evidence …
Linking transcriptomic and proteomic data on the level of protein interaction networks
P Perco, I Mühlberger, G Mayer, R Oberbauer… - …, 2010 - Wiley Online Library
… features, resulting from transcriptomics and proteomics, is for various reasons limited. We …
of protein interaction networks, exemplified by using transcriptomic and proteomic data sets …
of protein interaction networks, exemplified by using transcriptomic and proteomic data sets …
Analyzing protein–protein interaction networks
… Using the molecular interaction database IntAct, the software platform … based proteomics
experiment, we show how to build, visualize, and analyze a protein–protein interaction network. …
experiment, we show how to build, visualize, and analyze a protein–protein interaction network. …
From protein-protein interactions to protein co-expression networks: a new perspective to evaluate large-scale proteomic data
… A protein interaction network usually refers to physical PPIs [29], but several … interactions
composing a given network could not occur in any cell or at any time. However, if two interacting …
composing a given network could not occur in any cell or at any time. However, if two interacting …
PPI spider: a tool for the interpretation of proteomics data in the context of protein–protein interaction networks
AV Antonov, S Dietmann, I Rodchenkov… - …, 2009 - Wiley Online Library
… The “active sub-network” approach is sensitive to missing proteins and we demonstrate by
analyses of real data in many cases that it may fail to identify statistically significant models. …
analyses of real data in many cases that it may fail to identify statistically significant models. …
Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer
C Chen, H Shen, LG Zhang, J Liu… - International …, 2016 - spandidos-publications.com
… interactions specific to PCa proteomics-related proteins has been conducted. Therefore, to
put our proteomics data in … protein networks based on the available proteomics literature data) …
put our proteomics data in … protein networks based on the available proteomics literature data) …
Gaining confidence in high-throughput protein interaction networks
JS Bader, A Chaudhuri, JM Rothberg, J Chant - Nature biotechnology, 2004 - nature.com
… proteomics data remains a challenge. Here we develop a quantitative method for evaluating
proteomics data. … To avoid cross-contamination of data, we included only proteomics data in …
proteomics data. … To avoid cross-contamination of data, we included only proteomics data in …
Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics
ME Sardiu, Y Cai, J Jin, SK Swanson… - Proceedings of the …, 2008 - National Acad Sciences
… Finally, we constructed a probabilistic human interaction network composed of … proteomics
for organizing proteins into complexes and for generating probabilistic interaction networks. …
for organizing proteins into complexes and for generating probabilistic interaction networks. …
Protein interaction networks: Functional and statistical approaches
M Escandón, L Lamelas, V Roces… - Plant Proteomics …, 2020 - Springer
… In this chapter, different workflows that enable the creation of interaction networks are
proposed. Resulting networks reduce the complexity of original datasets, depicting complex …
proposed. Resulting networks reduce the complexity of original datasets, depicting complex …
Functional and topological characterization of protein interaction networks
… understanding the structure of protein interaction networks offers an important starting point
… interaction network of the yeast, Saccharomyces cerevisiae, aiming to uncover the network’…
… interaction network of the yeast, Saccharomyces cerevisiae, aiming to uncover the network’…
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