[HTML][HTML] Determination of the HLA-DM interaction site on HLA-DR molecules
… class II molecules and of HLA-DM have not permitted identification of their interaction sites.
Here, we describe mutations in class II that impair interactions with DM. Libraries of randomly …
Here, we describe mutations in class II that impair interactions with DM. Libraries of randomly …
[HTML][HTML] HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation
ED Mellins, LJ Stern - Current opinion in immunology, 2014 - Elsevier
… In the period covered by this review, significant progress has been made towards
understanding the structural basis for DM interaction with MHC-II, and new work strengthens the …
understanding the structural basis for DM interaction with MHC-II, and new work strengthens the …
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism
AI Guce, SE Mortimer, T Yoon, CA Painter… - Nature structural & …, 2013 - nature.com
… modulates HLA-DM function. We determined the X-ray crystal structure of HLA-DO bound to
HLA-DM … We measured the interaction of soluble DO and DM using biolayer interferometry. …
HLA-DM … We measured the interaction of soluble DO and DM using biolayer interferometry. …
Identification of the HLA-DM/HLA-DR interface
MN Davies, A Lamikanra, CE Sansom, DR Flower… - Molecular …, 2008 - Elsevier
… minimisation simulations to identify a putative interaction site of >4000 Å 2 which agrees
with known point mutational data for both the DR and DM molecule. The docked structure is …
with known point mutational data for both the DR and DM molecule. The docked structure is …
[HTML][HTML] Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides
… DM mutations identified an interaction surface, we mapped them on the crystal structure of
HLA-DM (… All six are surface exposed and located on the same lateral face of DM, with βE8, …
HLA-DM (… All six are surface exposed and located on the same lateral face of DM, with βE8, …
HLA‐DM: arbiter conformationis
A Ferrante - Immunology, 2013 - Wiley Online Library
… -DR2 variants, indicating that DM specifically binds DR molecules in which the N-terminal
site of the complex is emptied.51 Indeed, this study clearly showed that DM did not interact …
site of the complex is emptied.51 Indeed, this study clearly showed that DM did not interact …
HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules
LK Denzin, C Hammond, P Cresswell - The Journal of experimental …, 1996 - rupress.org
… Additionally, we examine the in vitro interaction of affinity-purified DM with DR molecules …
for αβCLIP in the interaction, and suggest that one function of HLA-DM is to prolong the survival …
for αβCLIP in the interaction, and suggest that one function of HLA-DM is to prolong the survival …
[HTML][HTML] Crystal structure of the HLA-DM–HLA-DR1 complex defines mechanisms for rapid peptide selection
… (B and E) Top view of the DM-DR1 complex shows the DM interaction site on the DRα chain
and a partially empty peptide-binding groove. DMα is colored red, DMβ yellow, DRα cyan, …
and a partially empty peptide-binding groove. DMα is colored red, DMβ yellow, DRα cyan, …
Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs.
SM van Ham, U Grüneberg, G Malcherek… - The Journal of …, 1996 - rupress.org
… These data are consistent with the observation of a transient interaction between DM and
DR`, irrespective of loading with cognate peptide or CLIP (21). The primary sequence of the …
DR`, irrespective of loading with cognate peptide or CLIP (21). The primary sequence of the …
[HTML][HTML] HLA-DM focuses on conformational flexibility around P1 pocket to catalyze peptide exchange
… As in the HLA-DM-HLA-DO structure, αW43 in HLA-DR1 rotates out of the lateral wall of
P1 pocket to directly interact with HLA-DM by forming a hydrogen bond with HLA-…
P1 pocket to directly interact with HLA-DM by forming a hydrogen bond with HLA-…
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