Intranasal administration for pain: oxytocin and other polypeptides

VN Bharadwaj, AZ Tzabazis, M Klukinov, NA Manering… - Pharmaceutics, 2021 - mdpi.com
pain, but not in men [61]. Similarly, a recent study on the perception of wound pain showed
that intranasal oxytocin reduced wound pain in … nerve—and have shown that nasal oxytocin

Intranasal oxytocin alleviates comorbid depressive symptoms in neuropathic pain via elevating hippocampal BDNF production in both female and male mice

R Liu, D Sun, X Xing, Q Chen, B Lu, B Meng, H Yuan… - …, 2024 - Elsevier
… Because of the advantage of intranasal delivery of oxytocin … effect of intranasal application
of oxytocin on neuropathic pain and … the effect of intranasal oxytocin on neuropathic pain and …

Intranasal oxytocin attenuates reactive and ongoing, chronic pain in a model of mild traumatic brain injury

AC Meidahl, A Eisenried, M Klukinov… - … Head and Face Pain, 2018 - Wiley Online Library
… is characterized by allodynia and resembles that found in other central neuropathic pain
patients.6 Headache is also a common post-TBI manifestation in humans and the symptoms …

Effects of intranasal oxytocin on pain perception among human subjects: A systematic literature review and meta-analysis

S Lopes, F de Lima Osório - Hormones and Behavior, 2023 - Elsevier
… The oxytocin intranasal administration did not directly affect pain perception. … the effects of
intranasal OXT on the self-perception of clinical and/or experimentally induced pain to gather …

Intranasal oxytocin administration is associated with enhanced endogenous pain inhibition and reduced negative mood states

BR Goodin, AJB Anderson, EL Freeman… - … journal of pain, 2015 - journals.lww.com
… of intranasal oxytocin was associated with pain sensitivity, endogenous pain inhibitory …
can also be taken up by the trigeminal nerve to various brainstem structures. Along this line, …

Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations

DC Yeomans, LR Hanson, DS Carson… - Translational …, 2021 - nature.com
… concentrations of oxytocin observed along the trigeminal nerve and pons, medulla, and
cerebellum in the present study appear to also suggest a route along the trigeminal nerve that …

Preliminary results from a randomized, controlled, cross-over trial of intrathecal oxytocin for neuropathic pain

JC Eisenach, RS Curry, TT Houle - Pain Medicine, 2023 - academic.oup.com
… administration at dose orders of magnitude greater than are tested in humans, and human
studies, which typically utilize intranasal oxytocin administration, are as likely to show no …

The effect of intranasal oxytocin administration on acute cold pressor pain: a placebo-controlled, double-blind, within-participants crossover investigation

JA Rash, TS Campbell - Psychosomatic medicine, 2014 - journals.lww.com
… treatment literature ( 2 ), despite adverse effects ( 3–5 ) and limited effectiveness in areas
such as neuropathic pain. There is a need for analgesics that are safe, have low adverse …

Evaluating the efficacy of intranasal oxytocin on pain and function among individuals who experience chronic pain: a protocol for a multisite, placebo-controlled …

JA Rash, TS Campbell, L Cooper, D Flusk… - BMJ open, 2021 - bmjopen.bmj.com
… with primary neuropathic painpain arising as a direct consequence of a lesion or disease
affecting the central or peripheral nervous system46—will be eligible. Neuropathic pain will …

Oxytocin and migraine headache

A Tzabazis, S Kori, J Mechanic, J Miller… - … Head and Face Pain, 2017 - Wiley Online Library
… This study provided strong support for intranasal oxytocin reaching key nerve pathways and
pain transmission. To test the hypothesis that intranasal oxytocin would affect CNS pain