… ) and VCAM-1 are upregulated relatively slowly after cytokine treatment. reaching a plateau
… endothelial venules of lymph nodes (5, 7). In adhesion of leukocytes to vascular endothelial …

… involved in leukocyteendothelial interactions … cancer or immune cells can modulate the
endothelial CAMs. This molecular link may partially explain why the overall leukocyte-endothelial …

… the interactions of leukocytes with the vessel wall, transient, reversible, P- and L-selectin-mediated
adhesive contacts between leukocytes and the endothelium (leukocyte rolling) are …

… the initial cell contact between leukocytes and endothelium which results in transient
tethering and rolling of leukocytes on cytokine activated endothelial cells. These binding events …

… of leukocytes … of cancer extravasation, since leukocyte diapedesis through the vasculature
involves critical adhesive interactions with endothelial cells, and both leukocytes and cancer …

… White blood cells then adhere to the activated endothelial cells, migrate through the vessel
… Sequential steps in the pathogenesis of cancer metastasis. To produce metastascs. tumor …

… cancer cells with blood constituents (platelets, leukocytes) can modulate their capacity to
adhere to endothelium in distant organs thereby facilitating metastasis. This process of …

… leukocyte over the vascular endothelium. Selectin expression is normally tightly regulated to
ensure that leukocytes tether to, and roll on, the endothelium at … including cancer metastasis. …

… , which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162) for leukocyte
rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto …

… lymphocytes on the venular endothelium surface. We report … independent of the presence
of metastasis into the LN and … that usually control leukocyte-endothelium interactions into the …