… by dysfunctional mitochondria reinforces lung fibroblast senescence … is activated, altering
mitochondrial homoeostasis and … by which mitochondria contribute to fibroblast senescence in …

… lung fibroblasts (55). Other putative mechanisms of loss of mitochondrial homeostasis in
aging/IPF lung fibroblasts … accompanies fibroblast mitochondrial dysfunction has been termed “…

… mitochondrial dysfunction affects different lung cell populations in the context of IPF, with a
focus on epithelial cells, fibroblasts … -1α is reduced in primary lung fibroblast isolated from IPF …

… with resulting mitochondrial dysfunction. Additionally, the ROS-producing enzyme NADPH
oxidase-4 (Nox4), which is upregulated in IPF lung fibroblasts, represses mitochondrial …

… This effect was observed in our results when using attrayloside or bongkrekic acid in the
control lung fibroblasts. We observed an increase in apoptosis when stimulated …

… We next hypothesized that the mitochondrial dysfunction and generation of ROS described
above in irradiated HFL1 cells could be due to adaptations in mitochondrial respiratory ETC …

… In lung fibroblasts, NOX4 inhibited mitochondrial bioenergetics and biogenesis through
decreasing induction and activation of endogenous nuclear factor (erythroid-derived-2)-like-2 …

… propose that mitochondrial biogenesis is needed for fibroblast … Interestingly, primary lung
fibroblasts derived from patients … , where senescent fibroblasts express increased levels of the …

… mitochondrial dysfunction and damaged mitochondrial DNA (… degenerative lung diseases,
pulmonary fibrosis, and lung … In a study of primary lung fibroblasts cultured from healthy or …

… Some studies suggest that mitochondrial dysfunction and oxidative stress may play a role in
… mitochondrial dysfunction and oxidative damage caused by AMD in human lung fibroblast …