Prevention of lymphocyte apoptosis—a potential treatment of sepsis?

RS Hotchkiss, CM Coopersmith… - Clinical Infectious …, 2005 - academic.oup.com
… The potential importance of apoptosis in the pathophysiology of sepsis is illustrated by …
lymphocyte apoptosis improves survival in sepsis. A variety of strategies to inhibit apoptosis may …

Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy

K Stahnke, S Fulda, C Friesen, G Strauß… - Blood, The Journal …, 2001 - ashpublications.org
… increased spontaneous apoptosis was found (data not shown). In order not to miss death
receptor–mediated lymphocyte apoptosis at early time points, we investigated lymphocytes at 3…

Evaluation of a combination “lymphocyte apoptosis model” to predict survival of sepsis patients in an intensive care unit

W Jiang, W Zhong, Y Deng, C Chen, Q Wang… - BMC …, 2018 - Springer
… We hypothesized that the combined lymphocyte apoptosis and immune function parameters
model (the “lymphocyte apoptosis model”) might have better specificity and/or sensitivity as …

Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations

XH Zhu, YL Shen, Y Jing, X Cai, PM Jia… - Journal of the …, 1999 - academic.oup.com
apoptosis and/or growth inhibition as well as on mitochondrial transmembrane potential (ΔΨ
m ) collapse in malignant lymphocyte … As 2 O 3 treatment in malignant lymphocytes by using …

Induction of T lymphocyte apoptosis by treatment with glycyrrhizin

C Oh, Y Kim, J Eun, T Yokoyama, M Kato… - The American journal …, 1999 - World Scientific
… by a reduction of mitochondrial membrane potential. In order to … the lymphocytes of the
GL-treated mice, we investigated the potential change in mitochondrial transmembrane potential (…

The role of apoptosis in the development and function of T lymphocytes

N Zhang, H Hartig, I Dzhagalov, D Draper, YW He - Cell research, 2005 - nature.com
… , apoptosis is required for lymphocyte development and homeostasis. The dysregulation of
apoptosis … In this review, we will address three topics: i) apoptosis pathways; ii) T lymphocyte

Induction of apoptosis in peripheral blood lymphocytes following treatment in vitro with hydroxychloroquine

XW Meng, JM Feller, JB Ziegler… - … : Official Journal of …, 1997 - Wiley Online Library
… in investigating whether HCQ exerts its effects through the modulation of apoptosis. Our
results showed that HCQ was able to induce apoptosis in peripheral blood lymphocytes. …

Biology and treatment of familial hemophagocytic lymphohistiocytosis: importance of perforin in lymphocyte‐mediated cytotoxicity and triggering of apoptosis

JI Henter - Medical and Pediatric Oncology: The Official Journal …, 2002 - Wiley Online Library
… Schematic illustration of major pathways involved in apoptosis triggering. Effector cells
such as the cytotoxic T lymphocyte (CTL) and NK cells may initiate apoptosis of target cells …

Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn's disease

J Doering, B Begue, MJ Lentze, F Rieux-Laucat… - Gut, 2004 - gut.bmj.com
… To address the question of a general T lymphocyte apoptosis defect in CD, we analysed and
compared Fas induced apoptosis of autologous LPL of highly inflammatory colonic mucosa …

Human lymphocyte apoptosis after exposure to influenza A virus

JE Nichols, JA Niles, NJ Roberts Jr - Journal of virology, 2001 - Am Soc Microbiol
… on the potential induction of apoptosis of lymphocytes by the virus. Analysis of lymphocyte
… , CD8 + , and CD19 + lymphocytes became apoptotic (terminal deoxynucleotidyltransferase-…