… /or time-modified regimens of temozolomide have been found to significantly improve outcome
of patients with malignant gliomas, the prognosis of these patients remains unsatisfactory. …

… in the treatment of malignant glioma and … temozolomide as an anticancer agent and
summarizes the most recent clinical studies of temozolomide for the treatment of malignant gliomas. …

… Options for chemotherapy at the time of recurrence in patients with malignant glioma are …
, compassionate-use protocol of temozolomide for patients with recurrent malignant glioma. …

… malignant glioma is not well documented in Chinese patients. Multicenter, randomized controlled
trials including appropriately sized patient … warranted in patients with malignant glioma. …

… CLINICAL EXPERIENCES WITH TEMOZOLOMIDE We have reviewed the most important
papers on TMZ use in malignant glioma. These studies have been found by search on web …

… in glioblastoma, 4,20 with no restriction on timing of failure with respect to previous temozolomide
… the typical population of patients entering studies of recurrent malignant gliomas (MGs) …

… the initial clinical outcomes of temozolomide therapy in high-grade malignant glioma.[2]
The … of temozolomide, mainly in advanced malignant gliomas and metastatic malignant …

… for elderly patients (defined as patients 70 years of age or older) with malignant gliomas (MG…
the observation that elderly patients do not tolerate adjuvant radiotherapy. The availability of …

… patients with GBM remains < 1 year from initial diagnosis (Friedman et al, 2000). Most patients
with malignant gliomas … 12% for patients with newly diagnosed GBM and 38% to 50% for …

… Five patients with malignant gliomas receiving long-term TMZ through the University of
Kentucky Neuro-Oncology Clinic were identified. Their charts were reviewed, including TMZ …