DNA methylation: a promising approach in management of Alzheimer's disease and other neurodegenerative disorders

G Kaur, SSS Rathod, MM Ghoneim, S Alshehri… - Biology, 2022 - mdpi.com
… of the disease and detect … association of DNA methylation with the pathogenesis of the
most common neurodegenerative diseases, such as, Alzheimer’s disease, Parkinson’s disease

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

N Coppieters, BV Dieriks, C Lill, RLM Faull… - Neurobiology of …, 2014 - Elsevier
… Global 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) levels in the gray
matter of Alzheimer's disease (AD) and control middle frontal gyri (MFG). Integrated intensity per …

Association of peripheral blood DNA methylation level with Alzheimer's disease progression

…, Alzheimer's Disease Neuroimaging Initiative (ADNI) - Clinical …, 2021 - Springer
… , logical memory delayed recall, Alzheimer Disease Assessment Scale-Cognitive Subscale
… method in R package BACON v1.10.1 to control for inflation of test statistics and for lambda …

Dynamics of DNA methylation in aging and Alzheimer's disease

HA Irier, P Jin - DNA and cell biology, 2012 - liebertpub.com
… of DNA methylation in neurodegenerative diseases, with a special focus on DNA methylation
… give us deeper insight into the disease etiology, aid in intervention and management of …

Epigenetic changes in Alzheimer's disease: decrements in DNA methylation

D Mastroeni, A Grover, E Delvaux, C Whiteside… - Neurobiology of …, 2010 - Elsevier
DNA methylation is a vital component of the … DNA methylation and eight methylation maintenance
factors in entorhinal cortex layer II, a region exhibiting substantial Alzheimer’s disease (…

[HTML][HTML] Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

L Chouliaras, D Mastroeni, E Delvaux, A Grover… - Neurobiology of …, 2013 - Elsevier
… Pooled data from the 3 hippocampal subregions of non-demented control cases (ND; open
bars) and Alzheimer's disease cases (AD; filled bars). The percentage of decrease in each …

DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

JV Sanchez-Mut, E Aso, N Panayotis, I Lott, M Dierssen… - Brain, 2013 - academic.oup.com
… are known to be deregulated by DNA methylation in case-control studies of Alzheimer’s …
APP-PSEN1 and 3xTg-AD Alzheimer's disease mouse models in relation to their corresponding …

Epigenetics in Alzheimer's disease: perspective of DNA methylation

TJ Qazi, Z Quan, A Mir, H Qing - Molecular Neurobiology, 2018 - Springer
… US Food and Drug Administration has approved many DNA methylation and histone
deacetylation inhibitors for blood tumors. In the past few years, epigenetic therapies for AD have …

Differential DNA methylation of microRNA genes in temporal cortex from Alzheimer's disease individuals

D Villela, RF Ramalho, ART Silva, H Brentani… - Neural …, 2016 - Wiley Online Library
… We removed one control sample from our analysis because it presented a low call rate.
Normalization and probe type bias adjustment were applied using BMIQ method [18]. We …

Epigenetics: Recent advances and its role in the treatment of Alzheimer's disease

X Xiao, X Liu, B Jiao - Frontiers in Neurology, 2020 - frontiersin.org
… Also, the administration of DNMT inhibitors is used in some neurodegenerative … Global
changes in DNA methylation in Alzheimer's disease peripheral blood mononuclear cells. Brain …