Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects
L Burdelya, M Kujawski, G Niu, B Zhong… - The Journal of …, 2005 - journals.aai.org
… cells can also attract immune cells. In this study, we show in isogenic murine melanomas
that natural Stat3 activity is associated with tumor growth and reduction of T cell infiltration. …
that natural Stat3 activity is associated with tumor growth and reduction of T cell infiltration. …
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
G Niu, T Bowman, M Huang, S Shivers, D Reintgen… - Oncogene, 2002 - nature.com
… might be responsible for Stat3 activation in melanoma cells, we … on Stat3 DNA-binding
activity in melanoma cell lines. To assess if JAKs are involved in Stat3 activation in melanoma cells…
activity in melanoma cell lines. To assess if JAKs are involved in Stat3 activation in melanoma cells…
The role of constitutively activated STAT3 in B16 melanoma cells
CH Yang, M Fan, AT Slominski, J Yue… - International journal of …, 2010 - Taylor & Francis
… We found that STAT3 activity increases melanoma invasiveness and is required for
active melanogenesis by regulating tyrosinase gene expression and enzyme activity. …
active melanogenesis by regulating tyrosinase gene expression and enzyme activity. …
Activation of stat3 in human melanoma promotes brain metastasis
… In the present study, we found that blockade of Stat3 activity in brain metastatic melanoma
cells suppressed angiogenesis in brain metastases in nude mice. The inhibition of brain …
cells suppressed angiogenesis in brain metastases in nude mice. The inhibition of brain …
ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis
… STAT3 phosphorylation in the two melanoma cell lines that exhibited marked changes in
MAPK/PI3K activities revealed a higher basal level of Ser 727 phosphorylation in LU1205 cells …
MAPK/PI3K activities revealed a higher basal level of Ser 727 phosphorylation in LU1205 cells …
[HTML][HTML] Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells
M Sakaguchi, M Oka, T Iwasaki, Y Fukami… - Journal of Investigative …, 2012 - Elsevier
… pS-STAT3 and the cell survival activity of melanoma cells was … effects of U0126 on cell survival
activity of melanoma cells were … the cell survival activity of all the four melanoma cell lines …
activity of melanoma cells were … the cell survival activity of all the four melanoma cell lines …
Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling
… STAT3 signaling pathway in melanoma cells by … the STAT3 signaling pathway in the
anti-melanoma activities of quercetin. Our experiments shows that quercetin inhibits melanoma cells …
anti-melanoma activities of quercetin. Our experiments shows that quercetin inhibits melanoma cells …
MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines
A Vultur, J Villanueva, C Krepler, G Rajan, Q Chen… - Oncogene, 2014 - nature.com
… We further show that downregulation of STAT3 activity or upstream RTKs prevent the … We
observed that confluence in our melanoma cells increases STAT3 phosphorylation, but the …
observed that confluence in our melanoma cells increases STAT3 phosphorylation, but the …
Role of ERp57 in the signaling and transcriptional activity of STAT3 in a melanoma cell line
S Chichiarelli, E Gaucci, A Ferraro, C Grillo… - Archives of biochemistry …, 2010 - Elsevier
… M14 melanoma cells showed that the protein ERp57 (endoplasmic reticulum protein 57)
binds to DNA in the proximity of STAT3 in a subset of STAT3-regulated genes. In the same cells, …
binds to DNA in the proximity of STAT3 in a subset of STAT3-regulated genes. In the same cells, …
[HTML][HTML] … curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity
… specifically inhibit the STAT3 signaling pathway to induce apoptosis in melanoma cells. …
the biologic activity of the FLLL32 curcumin analog on human melanoma and immune effector …
the biologic activity of the FLLL32 curcumin analog on human melanoma and immune effector …
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