The impact of hypoxia and mesenchymal transition on glioblastoma pathogenesis and cancer stem cells regulation
… cells lose their epithelial characteristics and take on a more mesenchymal phenotype, but
the mesenchymal transition in … related to the unique cell types and cellular organization in the …
the mesenchymal transition in … related to the unique cell types and cellular organization in the …
TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion
JV Joseph, S Conroy, T Tomar, E Eggens-Meijer… - Cell death & …, 2014 - nature.com
… Overall, our findings indicate that GBM cells can acquire mesenchymal features associated
… Our finding that TGFβ can induce mesenchymal transition provides another secretory factor …
… Our finding that TGFβ can induce mesenchymal transition provides another secretory factor …
Dual-specificity phosphatase (DUSP6) in human glioblastoma: epithelial-to-mesenchymal transition (EMT) involvement
C Zuchegna, E Di Zazzo, B Moncharmont… - BMC Research …, 2020 - Springer
… to-mesenchymal transition (EMT) in glioblastoma and its connection with the invasive capacity.
… Finally, we assayed invasive ability of both naïve glioblastoma cells compared to DUSP6-…
… Finally, we assayed invasive ability of both naïve glioblastoma cells compared to DUSP6-…
Investigating the link between molecular subtypes of glioblastoma, epithelial-mesenchymal transition, and CD133 cell surface protein
… cell surface protein. The contribution of this paper is three-fold: First, we use a newly identified
signature for epithelial-to-mesenchymal transition in human mammary epithelial cells… GBM …
signature for epithelial-to-mesenchymal transition in human mammary epithelial cells… GBM …
[HTML][HTML] Mesenchymal stem cells enhance tumorigenic properties of human glioblastoma through independent cell-cell communication mechanisms
CO Rodini, PBG da Silva, AF Assoni, VM Carvalho… - Oncotarget, 2018 - ncbi.nlm.nih.gov
… , migration, and epithelial-mesenchymal transition (EMT) of tumor cells [18]. TGFB1 is also
a well-known factor capable of increasing GBM cell proliferation and migration [19–22]. Given …
a well-known factor capable of increasing GBM cell proliferation and migration [19–22]. Given …
[HTML][HTML] HMGB1-induced p62 overexpression promotes snail-mediated epithelial-mesenchymal transition in glioblastoma cells via the degradation of GSK-3β
H Li, J Li, G Zhang, Q Da, L Chen, S Yu, Q Zhou… - Theranostics, 2019 - ncbi.nlm.nih.gov
… GBM patients. Hence, this study aimed to clarify the role of p62 in HMGB1-induced
epithelial-mesenchymal transition (EMT) of GBM … in both human GBM cell line and primary GBM …
epithelial-mesenchymal transition (EMT) of GBM … in both human GBM cell line and primary GBM …
[HTML][HTML] Metformin inhibits TGF-β1-induced epithelial-to-mesenchymal transition-like process and stem-like properties in GBM via AKT/mTOR/ZEB1 pathway
Y Song, Y Chen, Y Li, X Lyu, J Cui, Y Cheng, L Zhao… - Oncotarget, 2018 - ncbi.nlm.nih.gov
… in GBM cells remains to be unexplored. In this study, we found that metformin inhibited
EMT-like process in GBM cells and changed these cells to a less mesenchymal phenotype as …
EMT-like process in GBM cells and changed these cells to a less mesenchymal phenotype as …
[HTML][HTML] Metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity
X Yuan, W Wei, Q Bao, H Chen, P Jin… - Biomedicine & …, 2018 - Elsevier
… in glioma cells stemness and epithelial-mesenchymal transition. Here, we found that metformin
suppressed glioma cells spheroid formation and size, inhibited the expression of glioma …
suppressed glioma cells spheroid formation and size, inhibited the expression of glioma …
Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro …
G Stazi, L Taglieri, A Nicolai, A Romanelli… - Clinical …, 2019 - Springer
… In primary GBM cells as well as in U-87 GBM cells, the two compounds reduced H3K27me3
… impaired GBM cell viability without inducing apoptosis and arresting the cell cycle in the G0/…
… impaired GBM cell viability without inducing apoptosis and arresting the cell cycle in the G0/…
Paeoniflorin inhibits migration and invasion of human glioblastoma cells via suppression transforming growth factor β-induced epithelial–mesenchymal transition
Z Wang, Z Liu, G Yu, X Nie, W Jia, R Liu, R Xu - Neurochemical research, 2018 - Springer
… glioblastoma. However, the underlying mechanisms have not been fully elucidated. Epithelial
to mesenchymal transition (EMT), characterized as losing cell … to contribute to glioblastoma …
to mesenchymal transition (EMT), characterized as losing cell … to contribute to glioblastoma …