The impact of hypoxia and mesenchymal transition on glioblastoma pathogenesis and cancer stem cells regulation

M Karsy, J Guan, R Jensen, LE Huang, H Colman - World neurosurgery, 2016 - Elsevier
cells lose their epithelial characteristics and take on a more mesenchymal phenotype, but
the mesenchymal transition in … related to the unique cell types and cellular organization in the …

TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

JV Joseph, S Conroy, T Tomar, E Eggens-Meijer… - Cell death & …, 2014 - nature.com
… Overall, our findings indicate that GBM cells can acquire mesenchymal features associated
… Our finding that TGFβ can induce mesenchymal transition provides another secretory factor …

Dual-specificity phosphatase (DUSP6) in human glioblastoma: epithelial-to-mesenchymal transition (EMT) involvement

C Zuchegna, E Di Zazzo, B Moncharmont… - BMC Research …, 2020 - Springer
… to-mesenchymal transition (EMT) in glioblastoma and its connection with the invasive capacity.
… Finally, we assayed invasive ability of both naïve glioblastoma cells compared to DUSP6-…

Investigating the link between molecular subtypes of glioblastoma, epithelial-mesenchymal transition, and CD133 cell surface protein

H Zarkoob, JH Taube, SK Singh, SA Mani, M Kohandel - PloS one, 2013 - journals.plos.org
cell surface protein. The contribution of this paper is three-fold: First, we use a newly identified
signature for epithelial-to-mesenchymal transition in human mammary epithelial cellsGBM

[HTML][HTML] Mesenchymal stem cells enhance tumorigenic properties of human glioblastoma through independent cell-cell communication mechanisms

CO Rodini, PBG da Silva, AF Assoni, VM Carvalho… - Oncotarget, 2018 - ncbi.nlm.nih.gov
… , migration, and epithelial-mesenchymal transition (EMT) of tumor cells [18]. TGFB1 is also
a well-known factor capable of increasing GBM cell proliferation and migration [19–22]. Given …

[HTML][HTML] HMGB1-induced p62 overexpression promotes snail-mediated epithelial-mesenchymal transition in glioblastoma cells via the degradation of GSK-3β

H Li, J Li, G Zhang, Q Da, L Chen, S Yu, Q Zhou… - Theranostics, 2019 - ncbi.nlm.nih.gov
GBM patients. Hence, this study aimed to clarify the role of p62 in HMGB1-induced
epithelial-mesenchymal transition (EMT) of GBM … in both human GBM cell line and primary GBM

[HTML][HTML] Metformin inhibits TGF-β1-induced epithelial-to-mesenchymal transition-like process and stem-like properties in GBM via AKT/mTOR/ZEB1 pathway

Y Song, Y Chen, Y Li, X Lyu, J Cui, Y Cheng, L Zhao… - Oncotarget, 2018 - ncbi.nlm.nih.gov
… in GBM cells remains to be unexplored. In this study, we found that metformin inhibited
EMT-like process in GBM cells and changed these cells to a less mesenchymal phenotype as …

[HTML][HTML] Metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity

X Yuan, W Wei, Q Bao, H Chen, P Jin… - Biomedicine & …, 2018 - Elsevier
… in glioma cells stemness and epithelial-mesenchymal transition. Here, we found that metformin
suppressed glioma cells spheroid formation and size, inhibited the expression of glioma

Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro …

G Stazi, L Taglieri, A Nicolai, A Romanelli… - Clinical …, 2019 - Springer
… In primary GBM cells as well as in U-87 GBM cells, the two compounds reduced H3K27me3
… impaired GBM cell viability without inducing apoptosis and arresting the cell cycle in the G0/…

Paeoniflorin inhibits migration and invasion of human glioblastoma cells via suppression transforming growth factor β-induced epithelial–mesenchymal transition

Z Wang, Z Liu, G Yu, X Nie, W Jia, R Liu, R Xu - Neurochemical research, 2018 - Springer
glioblastoma. However, the underlying mechanisms have not been fully elucidated. Epithelial
to mesenchymal transition (EMT), characterized as losing cell … to contribute to glioblastoma