… In fact, carbapenems act as inhibitors for many β-lactamases by … -lactamases able to
hydrolyze carbapenems, including the class A carbapenemases and class B metallo-β-lactamases, …

… Two crystal structures have been reported for metallo-blactamases, one for the B. cereus II
… Substitution of lysine at position tion of an enterobacterial metallo b-lactamase found in a …

… other β-lactams differs between the different metallo-β-lactamases, and … metallo-β-lactamase
of Aeromonas hydrophila), to an extended range (eg, the VIM-type metallo-β-lactamases, …

… The genes encoding metallo-β-lactamases are often … Thus far, the metallo-β-lactamases
encoded on transferable … studies but also metallo-β-lactamase inhibitor studies securing the …

… Metallo-β-lactamases (MBLs) are a significant clinical problem because they hydrolyze
and inactivate nearly all β-lactam-containing antibiotics. These ‘lifesaving drugs’ constitute >50% …

… and the increasing detection of metallo-β-lactamase-producing pathogens by rapidly … which
they cleave β-lactams. In this review, recent work on metallo-β-lactamases from a variety of …

… Classes A, C and D are serine-β-lactamases which employ … , while metallo-β-lactamases
or class B β-lactamases are metallo-… Metallo-β-lactamases can degrade all classes of β-lactams …

… method has also been developed to detect metallo-β-lactamases, but again, this study …
metallo-β-lactamase (Etest MBL) strips for detection of a diverse range of metallo-β-lactamases…

… II metallo- β-lactamase, was identified in 1966 when the cephalosporinase activity of a β-lactamase
produced by a B… -type β-lactamase may be the most prevalent metallo-β-lactamase in …

The β-lactams are the most successful class of antibiotic drugs but they are vulnerable to … of
β-lactamases that now number more than a thousand variants. β-Lactamases operate by one …